Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed
since
about 13 years
ago
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Closed since about 13 years ago
674: CASP ROLL Target R0027 - Turkey Adenovirus
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL674: CASP ROLL Target R0027 - Turkey Adenovirus
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLThe next CASP ROLL target is another tough one. We are again providing you with 3 templates for now, and will give you some server predictions once they are released. Feel free to just work off the starting extended chain if you don't trust the alignments. More details about this CASP target are in the puzzle comments. Due to the size, we're giving you a few extra days to work on this one.
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Closed since about 13 years ago
675: Hydrogen-producing Catalyst Dimer (Fixed)
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry675: Hydrogen-producing Catalyst Dimer (Fixed)
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetryThis repost fixes the crashing bug with segment 2 being mutated to GLY. You can load your saved solutions from the previous puzzle to this one.
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Closed since over 13 years ago
673: CASP ROLL Target R0026 - Snake Adenovirus
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL673: CASP ROLL Target R0026 - Snake Adenovirus
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLCASP ROLL is back! This latest target is particularly difficult, as we have very low confidence in the templates (you will too once you see them!). We are providing you with 3 templates for now, and will give you some server predictions once they are released. Feel free to just work off the starting extended chain if you don't trust the alignments. More details about this CASP target are in the puzzle comments.
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Closed since over 13 years ago
This puzzle has been deprecated. Please reload your solutions in "675: Hydrogen-producing Catalyst Dimer (Fixed)"
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Closed since over 13 years ago
670: 30 Residue Symmetric Dimer of Dimers Freestyle Retry
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry670: 30 Residue Symmetric Dimer of Dimers Freestyle Retry
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetryPuzzle 670 is a small (30 residue) symmetric tetramer design puzzle. In other words you will be working with a protein that is made up of 4 symmetric chains. Symmetry becomes complicated when you are working with more than 3 chains. Tetramers, which we learned have 4 chains, can be arranged in a ring (called "C4" symmetry). Or, they can be arranged as a dimer of dimers ("D2" or "two-by-two" symmetry - 2 dimers put together forming a total of 4 symmetric sub-units). The dimer of dimers arrangement is much more common in nature. Keep in mind that symmetric proteins rely on more than just how well-folded each chain is. They also rely on how well the chains interface together. This protein has two fundamentally different interfaces: the interface between chains A and B, and the interface between dimer AB and its partner, CD.
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Closed since over 13 years ago
This puzzle starts out asymmetric but needs to be made symmetric. You can move one half of it to make it match the other half, and fit them together!
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Closed since over 13 years ago
We are giving you another currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
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Closed since over 13 years ago
We are giving you 5 server models for this protein. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. We would like to see how well you can refine these models that were not generated using Rosetta. More info about this protein in the puzzle comments.
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Closed since over 13 years ago
We are giving you this currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.