Foldit Puzzles

620: Quest to the Contact Map

In this puzzle, we've given you the contact map of the native. Open the contact by going to [Actions]>[Contact Map]. The white squares show which regions are next to each other in the native. Try to bring these regions closer to match the native, and increase your score multiplier. You can click on the squares to show you which pieces of the model need to be closer.

622: Quick Revisiting Puzzle 455 Part 2

We are reposting puzzle 455 to see how useful certain additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles. This time around, the cut tool is enabled, so feel free to use it.

618: Bonus Impossibly Difficult CASP10 Puzzle

The last CASP10 puzzle just closed, so we thought we'd post this tough target (for anyone going through CASP10 withdrawal) that we weren't able to give you during CASP. This refinement target, TR699, has a starting GDT_TS=85 and "should be treated as a dimer". Oh yes, and it's 234 residues! Read the puzzle comments for more details and how to deal with large proteins.

619: Quick Revisiting Puzzle 455

We are reposting puzzle 455 to see how useful certain additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles. Please note that the cut tool is disabled in this puzzle, as we will repost it again with the cut tool as another quick puzzle.

617: 40 Residue Symmetry Dimer Freestyle

This is a small (40 residue) symmetric dimer design puzzle. We think the 50 residue version of this puzzle was a little too long, so we've cut off 10 residues. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Stay tuned for more complex symmetries!

Beginner Puzzle: Potato Multicystatin

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles, or veteran players to help newer players. The starting model is completely wrong, can you use the Foldit tools you just learned to fix the model and match the guide?

616: Symmetric Beta Core Design Puzzle 2

This is part two of the small symmetric dimer design puzzle that uses a known structure as a starting point. We're interested to see what sort of designs you can come up with that respect the dimer symmetry, and fold around a central beta sheet. For the previous WXCXW puzzle we gave you an extended 20 residue chain at the C-terminus. We’ve moved that chain to the N terminus for this puzzle, which should allow for very different sorts of designs. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together!

615: CASP10 Refinement Puzzle: TR754

This is the twenty-fourth and final CASP10 Refinement Target. This model was the best server prediction for target T0754, generated by the Zhang Server. We've been told that ~77% of this model matches the native, so you'll need to refine ~23% of the structure. Luckily, this target only has 68 residues. More info in the puzzle comments.

614: CASP10 Refinement Puzzle: TR724

The twenty-third CASP10 Refinement Target was the best server prediction for target T0724, generated by the slbio server. We've been told that ~60% of this model matches the native, so you'll need to significantly change the starting model. More info in the puzzle comments.

613: CASP10 Refinement Puzzle: TR655

The twenty-second CASP10 Refinement Target was the best server prediction for target T0655, generated by the Tasser_VMT server. We've been told that ~69% of this model matches the native, so you'll need to significantly change the starting model. Luckily, they have told us which regions to focus on 1-15 & 46-59 (as well as which to ignore: residues 86-88 & 137-158). These regions are shown in Note Mode. More info in the puzzle comments.