Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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As mentioned in Puzzle 592, we are giving you some server predictions for this CASP10 target. Resetting the puzzle will cycle through 7 different server predictions and they are available in the Alignment Tool so you can use partial threading between them. You'll notice that some of them are similar to one another. Please try to work on each of the 7 server models, not just the one that gets you the most points after a couple days. The other models might get you a better score eventually!
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The thirteenth CASP10 target is another big one: 167 residues. We are providing you with 5 different templates, but two of them are the same protein with different alignments. We will provide you with server predictions soon. More details about this CASP target are in the puzzle comments.
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As mentioned in Puzzle 590, we are giving you some server predictions for this CASP10 target. Resetting the puzzle will cycle through 7 different server predictions and they are available in the Alignment Tool so you can use partial threading between them. Please try to work on each of the 7 server models, not just the one that gets you the most points after a couple days. The other models might get you a better score eventually!
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The twelfth CASP10 target is another tough one, as it's 154 residues. We are providing you with 4 different templates, but all of them have a similar topology (that we hope is the correct one!). We will provide you with server predictions soon. More details about this CASP target are in the puzzle comments.
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Closed
since
over 13 years
ago
This is the tenth CASP10 Refinement Target. This model was the best server prediction for target T0671, generated by the MUFOLD-Server. We've been told that only ~55% of this model matches the native, so (unlike previous CASP10 refinement puzzles) you'll need to significantly change the starting model. Luckily, this is a short target with only 88 residues. More info in the puzzle comments.
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This is a gallery of the native structure for the Foldit CASP9 Puzzle 1. You can look at the structure and interact with it, but there is no scoring recorded!
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This is a gallery of the native structure for the Foldit CASP9 Puzzle 2. You can look at the structure and interact with it, but there is no scoring recorded!
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As mentioned in Puzzle 585, we are giving you some server predictions for this CASP10 target. Resetting the puzzle will cycle through 7 different server predictions and they are available in the Alignment Tool so you can use partial threading between them. You'll notice that many of them are similar to one another. Please try to work on each of the 7 server models, not just the one that gets you the most points after a couple days. The other models might get you a better score eventually!
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Closed
since
over 13 years
ago
This is the original model given to us by CASP for the same target used in Puzzle 584. They have told us that 3 regions are "showing significant deviation", so please focus on changing the structure of those regions (highlighted in note mode). We've been told that ~72% of this model matches the native, so you shouldn't change the rest of the protein much. Much more info in the comments.
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Closed
since
over 13 years
ago
This is a small (30 residue) symmetric dimer design puzzle. We saw some very interesting structures for the related 20 residue puzzle (Puzzle 553), but adding ten residues should open up more fun low-energy design options without being too much to handle. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Stay tuned for three- and four-fold symmetry (trimers and tetramers) and polyhedra!