Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed since almost 14 years agoThis is the twelfth CASP10 Refinement Target. This model was the best server prediction for target T0723, generated by the Matrix server. We've been told that ~85% of this model matches the native, so you just need to find which 15% to refine! More info in the puzzle comments.
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Closed since almost 14 years ago
As mentioned in Puzzle 600, we are giving you server predictions for the last non-refinement CASP10 target. Resetting the puzzle will cycle through 8 different server predictions (that are similar to one another) and they are available in the Alignment Tool so you can use partial threading between them. Please try out each start, as the topology that initially scores poorly may actually be the closest to the native and will eventually score better than everything else.
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Closed since almost 14 years ago
Foldit's 600th puzzle is hopefully the last non-refinement CASP10 target! We are providing you with the top templates found by 3 different alignment programs. We will provide you with server predictions soon. More details about this CASP target are in the puzzle comments.
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Closed since almost 14 years ago
As mentioned in Puzzle 596, we are giving you server predictions for this CASP10 target. Resetting the puzzle will cycle through 9 different server predictions and they are available in the Alignment Tool so you can use partial threading between them. We are giving you extra time for this puzzle, so please try to work on each of the 9 server models. The topology that initially scores poorly may actually be the closest to the native and will eventually score better than everything else.
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Closed since almost 14 years ago
597: 50 Residue Symmetric Dimer Freestyle
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry597: 50 Residue Symmetric Dimer Freestyle
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetryThis is a small (50 residue) symmetric dimer design puzzle. We saw some very interesting structures in the smaller 20 and 30 residue freestyles. Using 50 residues puts this in the realm of a full-scale protein domain, and docking large secondary structure motifs becomes more viable. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together.
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Closed since almost 14 years ago
This is the eleventh CASP10 Refinement Target. This model was the best server prediction for target T0712, generated by the MUFOLD-Server. We've been told that ~92% of this model matches the native! So (for once) you won't need to change the starting model much. In addition, the organizers have told us "Regions worth specific attention: 43-52, 79-92, 104-118." These are highlighted in Note Mode.
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Closed since almost 14 years ago
The fourteenth CASP10 target is another big one: 165 residues and none of the alignment programs were able to find good templates for this target. It might be the case that this protein has no homologs. We are giving you 4 different templates (in hope that one of them is correct) for now, and will provide you with some server predictions soon. More details about this CASP target are in the puzzle comments.
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Closed since almost 14 years ago
This puzzle is for veteran Foldit players to help new players, and practice using Rebuild after changing the structure (see puzzle comments for more info).
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Closed since almost 14 years ago
595: 30 Residue Symmetric Trimer Freestyle
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry595: 30 Residue Symmetric Trimer Freestyle
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetryThis is a small (30 residue) symmetric trimer design puzzle; there will be three symmetric chains to play with. We saw some very interesting structures for the related 20 residue puzzle (Puzzle 553), but ten extra residues, and three-fold symmetry, should make this a very different challenge. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together - and a symmetric trimer can be thought of as having three 2-fold interfaces. Stay tuned for higher-order symmetries, like tetrahedra and octahedra!
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Closed since almost 14 years ago
As mentioned in Puzzle 592, we are giving you some server predictions for this CASP10 target. Resetting the puzzle will cycle through 7 different server predictions and they are available in the Alignment Tool so you can use partial threading between them. You'll notice that some of them are similar to one another. Please try to work on each of the 7 server models, not just the one that gets you the most points after a couple days. The other models might get you a better score eventually!