Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed
since
over 13 years
ago
Not only is the eighth CASP10 Refinement Target 223 residues, but this best server prediction for target T0679 was generated by the RosettaServer (using Rosetta@home). Because of this, we are giving you the Rosetta model as a template using the Alignment Tool minus the regions the CASP assesors have told us are incorrect; start by threading it and fixing the cutpoints. This one will be tough, so we are giving you 10 days. More info in the puzzle comments.
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Closed
since
over 13 years
ago
The eighth CASP10 Refinement Target has 224 residues! This model was the best server prediction for target T0681, generated by the MULTICOM-CONSTRUCT server. We've been told that ~78% of this model matches the native, so you just need to find which 22% to refine! We are giving you a couple extra days to work on this one due to its size. More info in the puzzle comments.
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This is a small (40 residue) symmetric dimer design puzzle. We saw some very interesting structures for the related 20 residue puzzle (#553). Adding twenty residues puts this in the realm of full-scale protein domain, and docking large secondary structure motifs becomes more viable. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Stay tuned for three- and four-fold symmetry (trimers and tetramers) and polyhedra!
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This is a small (20 residue) symmetric dimer design puzzle. We're interested to see what sort of structures you can come up with that respect the dimer symmetry. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together!
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The eleventh CASP10 target is not an easy one. It's 152 residues and none of the alignment programs were able to find good templates for this target. It might be the case that this protein has no homologs. We are giving you 6 templates (in hope that one of them is correct) for now, and will provide you with some server predictions once they are released. More details about this CASP target are in the puzzle comments.
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Closed
since
over 13 years
ago
The seventh CASP10 Refinement Target has 234 residues! This model was the best server prediction for target T0689, generated by the Jiang_Fold server. We've been told that ~87% of this model matches the native, so you just need to find which 13% to refine! We are giving you a couple extra days to work on this one due to its size. More info in the puzzle comments.
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Closed
since
over 13 years
ago
This is the sixth CASP10 Refinement Target. This model was the best human prediction for target T0674. We've been told that ~84% of this model matches the native, so you just need to find which 16% to refine! More info in the puzzle comments.
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The tenth CASP10 will look familiar: it's also 33 residues and the 3 different templates we are giving you are the same as Puzzle 574's. Note the short deadline, since this target is so small. More details about this CASP target are in the puzzle comments.
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We are looking for the best locations to place & design FIVE linked residues on the surface of Influenza H3 Hemagglutinin. We have placed 2 helices on either side so that it will be easier to build scaffolds for your designs. Mutate the 5 sidechains while looking for good hydrophobic pockets or residues to make strong hydrogen bonds to. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle.
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Closed
since
over 13 years
ago
This is the fourth CASP10 Refinement Target. This model was the best server prediction for target T0662, generated by the Zhang server. We've been told that ~84% of this model matches the native, so you just need to find which 16% to refine! More info in the puzzle comments.