Foldit Puzzles

560: Quick CASP10 T0660 Puzzle

This puzzle is very similar to puzzle 557. Again, most of the server predictions for T0660 were very similar except for the last 50 residues. Getting this C-terminal region right will separate the best predictions from the worst ones for this CASP10 target. Focus on folding the last 50 residues with the rest of the protein. You can use the Alignment Tool to insert a cutpoint between these regions. More info in the puzzle comments.

558: CASP10 Target T0668

Just to warn you: this one is going to be tough! None of the alignment programs were able to find good templates for this target, and it might be the case that this protein has no homologs. Therefore we are giving you 6 templates (in hope that one of them is correct) for now, and will provide you with some server predictions once they are released. More details about this CASP target are in the puzzle comments.

556: CASP10 Target T0660

Here is the second CASP10 target. This target is 108 residues and we are giving you the top-predicted templates from 3 different alignment programs. Make sure to try out all 3 templates since we don't know which one is closer to the correct native structure! More details about this CASP target are in the puzzle comments.

557: Quick CASP10 T0644 Puzzle

Most of the server predictions for T0644 were very similar except for the first 32 residues (the region that was unaligned to the starting template). Getting this N-terminal region right (which is strongly predicted to be helical) will separate the best predictions from the worst ones for this CASP10 target. For this quick puzzle: focus on folding the first 32 residues with the rest of the protein. Please read the puzzle comments about fixing an error in the starting model!

555: Symmetric Beta Core Design Puzzle 1

The ...WXCXW... motif adopts a remarkably stable homodimer structure. In fact, it's so tiny, it is difficult to use as a building block for bioengineering; it needs to be larger but retain rigidity. Otherwise anything goes: beta sheets, alpha helix docking, rigid loops, you name it. We've given you 20 extra residues to play with. See what you can do! (Hint: select some residues, set secondary structure to sheet or helix, and hit Rebuild for some quick helices or sheets)

554: Quest to the Native CASP ROLL Target R0007

We were hoping to post new CASP 10 puzzles, but so far, this week's targets are too big for Foldit. The native for CASP ROLL target R0007 was released, however, and one of the Zhang server models was a lot closer than the other 14 server models we gave you. We are giving you just that starting model and the native as a guide so you can see what changes needed to be made. This will be good practice for future CASP 10 puzzles that have no templates. This puzzle's deadline will be extended if we don't post two new CASP 10 targets this week.

554 (<15): Quest to the Native CASP ROLL Target R0007

We were hoping to post new CASP 10 puzzles, but so far, this week's targets are too big for Foldit. The native for CASP ROLL target R0007 was released, however, and one of the Zhang server models was a lot closer than the other 14 server models we gave you. We are giving you just that starting model and the native as a guide so you can see what changes needed to be made. This will be good practice for future CASP 10 puzzles that have no templates. This puzzle's deadline will be extended if we don't post two new CASP 10 targets this week. For players with fewer than 15 global points.

554 (<150): Quest to the Native CASP ROLL Target R0007

We were hoping to post new CASP 10 puzzles, but so far, this week's targets are too big for Foldit. The native for CASP ROLL target R0007 was released, however, and one of the Zhang server models was a lot closer than the other 14 server models we gave you. We are giving you just that starting model and the native as a guide so you can see what changes needed to be made. This will be good practice for future CASP 10 puzzles that have no templates. This puzzle's deadline will be extended if we don't post two new CASP 10 targets this week. For players with fewer than 150 global points.

553: Symmetric Dimer Freestyle

This is a small (20 residue) symmetric dimer design puzzle. We're interested to see what sort of structures you can come up with that respect the dimer symmetry. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together!

552: CASP10 Target T0644

Here is the first CASP10 target. This target is 166 residues and we are giving you the top-predicted template from 3 different alignment programs (you'll notice that all 3 programs picked the same template, but slightly different alignments). More details about this CASP target are in the puzzle comments.