Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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In this puzzle we are trying to determine the best locations to place & design 3 linked residues on a new region of the Influenza surface. Mutate the 3 sidechains while looking for good hydrophobic pockets or residues to make strong hydrogen bonds to. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle.
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This is a preview of one of the upcoming Symmetry Puzzles. You can view it in Gallery Mode for today's Scientist Chat. The ...WXCXW... motif adopts a remarkably stable homodimer structure. In fact, it's so tiny, it is difficult to use as a building block for bioengineering; the domain needs to be larger but retain rigidity. Otherwise anything goes: beta sheets, alpha helix docking, rigid loops, you name it. We've given you 20 extra residues to play with, and frozen the core. See what you can do!
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Closed
since
almost 14 years
ago
This is a repost of 544: Electron Density Puzzle 8b. The difference this time is that you're rewarded for fitting the density more. You're starting with an extended chain again, but you can load in your solutoins from 8b. Try to fit the protein into the density cloud to gain points, but remember that since this is real world data, sometimes you'll get more points for ignoring the density in certain areas.
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Closed
since
almost 14 years
ago
This is a repost of 535: Electron Density Puzzle 8. This time, however, you're starting with an extended chain. Try to fit the protein into the density cloud to gain points, but remember that since this is real world data, sometimes you'll get more points for ignoring the density in certain areas. We plan on re-posting this puzzle with the ability to load in solutions with some minor changes after this puzzle expires.
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In this puzzle we are trying to determine the best locations to place & design THREE linked residues on the surface of Influenza H3 Hemagglutinin. Mutate the 3 sidechains while looking for good hydrophobic pockets or residues to make strong hydrogen bonds to. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle.
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Closed
since
almost 14 years
ago
This advanced puzzle requires using the new cutpoints in the Alignment Tool. There is only one template you can thread with, but unfortunately the alignment is incorrect. This is not a blind target, but is perfect practice for the Template-Based category in CASP 10. More info about this in the puzzle comments. Make sure to complete and understand Intro Puzzles 6-1 through 6-3 before attempting this difficult puzzle.
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Closed
since
almost 14 years
ago
We are giving you the 5 BAKER-ROSETTASERVER predictions for R0018 (generated using Rosetta@home). Resetting the puzzle will cycle through these 5 server models and they are available in the Alignment Tool so you can use partial threading between them. Please try working on each of the 5 models, not just the one that gets you the most points after a couple days. The other models might get you a better score eventually!
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Closed
since
almost 14 years
ago
We are again letting you modify the structure of the small protein that binds to the flu virus (you can still mutate the sidechains). The Flu Virus is still frozen and a bit different this time. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, & 7-1 through 7-4. See the puzzle comments for more info about these Flu Puzzles.
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Closed
since
almost 14 years
ago
We are giving you 3 linked residues and your job is try to design and fit them into a constrained region of the CTLA-4 protein. We know the general region in which we want you to place to residues, but we don't know exactly where is the best spot; look for good hydrophobic pockets or residues to make strong hydrogen bonds to. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle.
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Closed
since
almost 14 years
ago
We are giving you the 5 BAKER-ROSETTASERVER predictions for R0014 (generated using Rosetta@home). Resetting the puzzle will cycle through these 5 server models and they are available in the Alignment Tool so you can use partial threading between them. Please try working on each of the 5 models, not just the one that gets you the most points after a couple days. The other models might get you a better score eventually!