Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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We are starting you off with server predictions for CASP ROLL target R0018. Resetting the puzzle will cycle through 7 different server predictions (we have filtered out server predictions similar to one another). Please work on each of the 7 server models, not just the one that gets you the most points after a couple days. The other models might get you a better score eventually! The secondary structure predictions are posted in the puzzle comments.
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Help fix this novel carbon-fixing enzyme. In this second puzzle of a series, the ligand score has been up-weighted and insertions have been disabled for the C-terminus. As in Puzzle 529, 7 residues can be added, and up to 10 can be removed. Here in lab, we are busily testing player designs from Puzzle 529, and hope to have results in the upcoming months to share with the Foldit community.
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Closed
since
almost 14 years
ago
Up until now, we've been posting contrived electron densities in order to help us refine the software and puzzle parameters. We now feel confident that both players and tools are ready for real-world densities that are generated from experimental data. For this puzzle, we've taken a large protein and broken it up into 3 domains. This puzzle gives you the smallest of the domains, made up of 2 different chains, along with the electron density that was generated from experimental data. As always, try to fit the density - but keep in mind that real world data isn't quite a ideal as previous puzzles, and it's possible it might be wrong or imprecise in areas.
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Closed
since
almost 14 years
ago
We are giving you the 5 BAKER-ROSETTASERVER predictions for R0013 (generated using Rosetta@home). Resetting the puzzle will cycle through these 5 server models and they are available in the Alignment Tool so you can use partial threading between them. Please try working on each of the 5 models, not just the one that gets you the most points after a couple days. The other models might get you a better score eventually!
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Closed
since
almost 14 years
ago
We are giving you the 5 BAKER-ROSETTASERVER predictions for R0011 (generated using Rosetta@home). Resetting the puzzle will cycle through these 5 server models and they are available in the Alignment Tool so you can use partial threading between them.
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Closed
since
almost 14 years
ago
We are giving you the 5 BAKER-ROSETTASERVER predictions for R0009 (generated using Rosetta@home) Resetting the puzzle will cycle through these 5 server models and they are available in the Alignment Tool so you can use partial threading between them. As requested in the Scientist Chat, this puzzle will be up for 11 days. So please work on each of the 5 models, not just the one that gets you the most points after a couple days! The other models might get you a better score eventually!
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In this puzzle we are trying to determine the best locations to place two linked residues on the surface of Influenza H3 Hemagglutinin. We have given you distance constraints because we know the general region in which we want you to place to residues. However, we don't know exactly where is the best spot; look for good hydrophobic pockets or residues to make strong hydrogen bonds to. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle.
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Closed
since
almost 14 years
ago
We are giving you the 5 BAKER-ROSETTASERVER predictions for R0010 (generated using Rosetta@home) before CASP ROLL target R0010 closes next week. Resetting the puzzle will cycle through these 5 server models and they are available in the Alignment Tool so you can use partial threading between them.
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This is the final Grand Challenge Puzzle in the current series. More information will be coming as to what we plan to do next, including all hands puzzles and eventually design.
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We are starting you off with server predictions for CASP ROLL target R0014. Resetting the puzzle will cycle through 10 different server predictions that are also available in the Alignment Tool so you can use partial threading. As requested in the Scientist Chat, this puzzle will be up for 11 days. So please work on each server model, not just the one that gets you the most points initially! The secondary structure predictions are posted in the puzzle comments.