Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Help fix this novel carbon-fixing enzyme. Try varying loop length and structures to make better scoring interactions with the ligand. In this puzzle, the first of a series, up to 7 residues can be added, and up to 10 can be removed. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, 7-1 through 7-4, 8-1 & 8-2 before trying this Advanced Science Puzzle. More info in the puzzle comments.
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We are starting you off with server predictions for CASP ROLL target R0013. Resetting the puzzle will cycle through 9 different server predictions that are also available in the Alignment Tool so you can use partial threading. As requested in the Scientist Chat, this puzzle will be up for 10 days. So please work on each server model, not just the one that gets you the most points initially! The secondary structure predictions are posted in the puzzle comments.
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We are starting you off with server predictions for CASP ROLL target R0011. Luckily, this is a shorter target: only 81 residues. Resetting the puzzle will cycle through 10 different server predictions that are also available in the Alignment Tool so you can use partial threading. As requested in the Scientist Chat, this puzzle will be up for 10 days. So please work on each server model, not just the one that gets you the most points initially! The secondary structure predictions are posted in the puzzle comments.
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Closed
since
about 14 years
ago
We are giving you the 5 BAKER-ROSETTASERVER predictions for R0003 (generated using Rosetta@home) before CASP ROLL target R0003 finally closes next week. Resetting the puzzle will cycle through these 5 server models and they are available in the Alignment Tool so you can use partial threading between them.
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We are starting you off with server predictions for CASP ROLL target R0010. Luckily, this is a shorter target: only 80 residues. Resetting the puzzle will cycle through 10 different server predictions that are also available in the Alignment Tool so you can use partial threading. As requested in the Scientist Chat, this puzzle will be up for 10 days. So please work on each server model, not just the one that gets you the most points initially! The secondary structure predictions are posted in the puzzle comments.
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Closed
since
about 14 years
ago
We are giving you three of the QUARK server predictions for R0008, but you will be able to manipulate them as dimers using symmetry. You'll want to look for a hydrophobic patch where both sections come together. Coloring by Hydro can help you try to get as much orange at the interface as possible. Please try optimizing all three different topologies. More explanations and hints are in the puzzle comments.
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The CASP ROLL organizers have told us that the native solved structure for R0007 forms "a noncovalent dimer". We are giving you the top 5 Foldit predictions from Puzzle 515, but you will be able to manipulate them as dimers using symmetry. You'll want to turn off all sidechains and visualizations, as this puzzle will likely crash many computers since this was already a large target. You should not spend too much time on this puzzle, it should really just be for fun. Therefore it will only be worth 20 global points.
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The ninth CASP ROLL target, R0009, is unfortunately another big protein and again we are starting you off with server predictions. Resetting the puzzle will cycle through 10 different server predictions that are also available in the Alignment Tool so you can use partial threading. The secondary structure predictions are posted in the puzzle comments. If you have trouble loading this puzzle, try checking the box "disable network timeouts" when you login.
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This puzzle is about trying to build a scaffold around a known binding helix to the H1 flu. We already have a few designs that we like from the computers that you can use as inspiration (see puzzle comments). While our designs are based on proteins that are known to exist, we are excited to see what you can build from scratch.
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We had to close this puzzle due to a bug. It has been reposted as Puzzle 522b where you can load in your previous 522 solutions. We apologize for this mistake and have added a couple hours to 522b's deadline.