Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed since about 14 years ago527: CASP ROLL Target R0013
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction527: CASP ROLL Target R0013
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionWe are starting you off with server predictions for CASP ROLL target R0013. Resetting the puzzle will cycle through 9 different server predictions that are also available in the Alignment Tool so you can use partial threading. As requested in the Scientist Chat, this puzzle will be up for 10 days. So please work on each server model, not just the one that gets you the most points initially! The secondary structure predictions are posted in the puzzle comments.
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Closed since about 14 years ago
526: CASP ROLL Target R0011
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction526: CASP ROLL Target R0011
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionWe are starting you off with server predictions for CASP ROLL target R0011. Luckily, this is a shorter target: only 81 residues. Resetting the puzzle will cycle through 10 different server predictions that are also available in the Alignment Tool so you can use partial threading. As requested in the Scientist Chat, this puzzle will be up for 10 days. So please work on each server model, not just the one that gets you the most points initially! The secondary structure predictions are posted in the puzzle comments.
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Closed since about 14 years ago
525: RosettaServer CASP ROLL R0003 Predictions
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction525: RosettaServer CASP ROLL R0003 Predictions
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionWe are giving you the 5 BAKER-ROSETTASERVER predictions for R0003 (generated using Rosetta@home) before CASP ROLL target R0003 finally closes next week. Resetting the puzzle will cycle through these 5 server models and they are available in the Alignment Tool so you can use partial threading between them.
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Closed since about 14 years ago
523: CASP ROLL Target R0010
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction523: CASP ROLL Target R0010
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionWe are starting you off with server predictions for CASP ROLL target R0010. Luckily, this is a shorter target: only 80 residues. Resetting the puzzle will cycle through 10 different server predictions that are also available in the Alignment Tool so you can use partial threading. As requested in the Scientist Chat, this puzzle will be up for 10 days. So please work on each server model, not just the one that gets you the most points initially! The secondary structure predictions are posted in the puzzle comments.
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Closed since over 14 years ago
524: Symmetry CASP ROLL R0008 Puzzle
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry524: Symmetry CASP ROLL R0008 Puzzle
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetryWe are giving you three of the QUARK server predictions for R0008, but you will be able to manipulate them as dimers using symmetry. You'll want to look for a hydrophobic patch where both sections come together. Coloring by Hydro can help you try to get as much orange at the interface as possible. Please try optimizing all three different topologies. More explanations and hints are in the puzzle comments.
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Closed since over 14 years ago
The CASP ROLL organizers have told us that the native solved structure for R0007 forms "a noncovalent dimer". We are giving you the top 5 Foldit predictions from Puzzle 515, but you will be able to manipulate them as dimers using symmetry. You'll want to turn off all sidechains and visualizations, as this puzzle will likely crash many computers since this was already a large target. You should not spend too much time on this puzzle, it should really just be for fun. Therefore it will only be worth 20 global points.
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Closed since over 14 years ago
519: CASP ROLL Target R0009
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction519: CASP ROLL Target R0009
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionThe ninth CASP ROLL target, R0009, is unfortunately another big protein and again we are starting you off with server predictions. Resetting the puzzle will cycle through 10 different server predictions that are also available in the Alignment Tool so you can use partial threading. The secondary structure predictions are posted in the puzzle comments. If you have trouble loading this puzzle, try checking the box "disable network timeouts" when you login.
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Closed since over 14 years ago
This puzzle is about trying to build a scaffold around a known binding helix to the H1 flu. We already have a few designs that we like from the computers that you can use as inspiration (see puzzle comments). While our designs are based on proteins that are known to exist, we are excited to see what you can build from scratch.
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Closed since over 14 years ago
522: Flu Design Puzzle 5
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Design Design Design522: Flu Design Puzzle 5
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Design Design DesignWe had to close this puzzle due to a bug. It has been reposted as Puzzle 522b where you can load in your previous 522 solutions. We apologize for this mistake and have added a couple hours to 522b's deadline.
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Closed since over 14 years ago
520: RosettaServer CASP ROLL R0007 Predictions
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction520: RosettaServer CASP ROLL R0007 Predictions
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionWe are giving you the 5 BAKER-ROSETTASERVER predictions for R0007 (generated using Rosetta@home) before providing you with the top Foldit predictions from Puzzle 515. Resetting the puzzle will cycle through these 5 server models and they are available in the Alignment Tool so you can use partial threading between them.