Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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This is the first in a new set of flu puzzles inspired by some of your previous work. These puzzles are all different protein binders but the way in which they bind is very similar. We look forward to seeing your results! If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, & 7-1 through 7-4. See the puzzle comments for more design puzzle help.
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We are revisting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles. The sixth Revisiting Puzzle also goes back to May 2009: http://fold.it/portal/node/986135
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This advanced puzzle requires using the Alignment Tool. There is only one template you can thread with, but unfortunately the alignment is incorrect. You will need to master Intro Puzzles 6-1 through 6-3 to succeed in this puzzle. Make sure to move the alignment around and try to help Foldit resolve the gaps in the alignment (see puzzle comments for tips).
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Closed
since
over 14 years
ago
This is a repost of Puzzle 457, but this time we've added some homology-based constraints. Players will NOT be able to load in any previous solutions for this puzzle, we want to see how different your folding is when guided by these constraints.
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This is a repost of Puzzle 457, but this time we've added some homology-based constraints. Players will NOT be able to load in any previous solutions for this puzzle, we want to see how different your folding is when guided by these constraints. For players with fewer than 15 global points.
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This is a repost of Puzzle 457, but this time we've added some homology-based constraints. Players will NOT be able to load in any previous solutions for this puzzle, we want to see how different your folding is when guided by these constraints. For players with fewer than 150 global points.
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Closed
since
over 14 years
ago
*** This puzzle has been taken down due to bugs *** This is the first symmetry puzzle - a small symmetric dimer. The structure is mostly correct - your job is to try and match the two subunits together so that they interface as well as possible. Your changes will be reflected in the symmetric unit. Brush up on the use of the move tool (Intro Puzzle 5-2) - you'll need it.
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Closed
since
over 14 years
ago
Introduction of Nanog into skin cells can help convert or 'reprogram' them into a state that is more stem cell-like. Solving this protein structure will help us design drugs that can activate Nanog and its binding partners as a strategy for patient-specific tissue regeneration. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. This puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.
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We are revisting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles. The fifth Revisiting Puzzle also goes back to May 2009: http://fold.it/portal/node/986148
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Closed
since
over 14 years
ago
This U2 small nuclear ribonucleoprotein auxiliary factor protein is currently unsolved by x-ray crystallography. We are giving it to you as a freestyle puzzle. Please use the secondary structure predictions that are posted in the puzzle comments, as we believe them to be very accurate. We have included them in the starting structure as well.