Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed since over 14 years ago*This puzzle has been taken down due to a bug. It will be reposted at a future date with the ability to load in solutions* In local refinement puzzles, your job is to find the region of the protein that needs the most work and improve that region to get the top score. You can choose which area you want to work on by going through the different starts of the puzzle (there are 10 starts in all, and you may access these by resetting the puzzle, which will give you the next start).
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Closed since over 14 years ago
This puzzle is designed for veteran Foldit players to help new players, so this version of the puzzle is only worth global 50 points.
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Closed since over 14 years ago
We are reposting the first CASP ROLL target, R0001, but this time we are providing you with server predictions. Resetting the puzzle will cycle through 10 different server predictions. They are also available in the Alignment Tool so you can use partial threading. We are giving you over 3 weeks (and 250 points) to work on this so please make sure to try out all 10 models! If you have trouble loading this puzzle, try checking the box "disable network timeouts" when you login.
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Closed since over 14 years ago
In this puzzle, we've cut up the protein into chunks of loops, sheets, and helices. Use the Move Tool (Acessible by clicking on the segment you want to move) and reposition the secondary structures into their correct positions. You'll need the latest update to play this puzzle.
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Closed since over 14 years ago
This is a repost of the third CASP ROLL target, R0003. Since this target has many Cysteines, we have enabled disulfide bonding for this puzzle. More info about Disulfide Bridges in Foldit here: http://foldit.wikia.com/wiki/Disulfide_Bridge. Once formed, you'll need to click "Show Bonds (sidechain)" to view them. You can load in your previous solutions from Puzzle 495.
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Closed since over 14 years ago
498: Electron Density Puzzle 6
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density498: Electron Density Puzzle 6
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron DensityThis is a repost of 473 (Electron Density Puzzle 5). We've adjusted the scoring of this puzzle to reward you more for conforming to the Electron Density. To get started, try playing the Electron Density intro puzzle.
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Closed since over 14 years ago
The third CASP ROLL target, R0003, is only 33 residues! We are giving it to you as a freestyle puzzle, so try to fold it in every possible way you can think of. The secondary structure predictions are useless, but you can view them in the puzzle comments. Have fun with this one, it's not due until March.
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Closed since over 14 years ago
Can you make the loop better before this puzzle closes on Friday?
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Closed since over 14 years ago
The second CASP ROLL target, R0002, is 197 residues! We are giving it to you as a freestyle puzzle while we wait for the server predictions to come back. We are providing you with secondary structure predictions that are posted in the puzzle comments and included (only the strong predictions) in the starting structure as well. Again, the deadlline isn't until February!
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Closed since over 14 years ago
490: Symmetric Foldon Puzzle 1
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry490: Symmetric Foldon Puzzle 1
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetryFoldon is a small, 27 residue domain from the C-terminus of a phage virus protein called fibritin. Your job is to fold 3 chains into a larger trimeric domain that includes foldon. You'll be allowed to move foldon around as well, but you can only mutate the residues in the polyalanine extension. And remember, three-fold symmetry will be enforced! If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, & 7-1 through 7-4. More details in the blog.