Foldit Puzzles

490: Symmetric Foldon Puzzle 1

Foldon is a small, 27 residue domain from the C-terminus of a phage virus protein called fibritin. Your job is to fold 3 chains into a larger trimeric domain that includes foldon. You'll be allowed to move foldon around as well, but you can only mutate the residues in the polyalanine extension. And remember, three-fold symmetry will be enforced! If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, & 7-1 through 7-4. More details in the blog.

493: Quick Flu Design Puzzle 3

This is the third in a new set of flu puzzles inspired by some of your previous work. These puzzles are all different protein binders but the way in which they bind is very similar. We look forward to seeing your results! If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, & 7-1 through 7-4. See the puzzle comments for more design puzzle help.

487: CASP ROLL Puzzle 1

This is the first CASP ROLL target: R0001. We are giving it to you as a freestyle puzzle while we wait for the server predictions to come back. We are providing you with secondary structure predictions that are posted in the puzzle comments and included in the starting structure as well. It's 183 residues long, but get used to this protein because it's deadlline isn't until February!

478: New Player Puzzle: Mycobacterium Tuberculosis Protein

This puzzle is designed for veteran Foldit players to help new players, so this version of the puzzle is only worth global 50 points.

489: Quick Flu Design Puzzle 2

This is the second in a new set of flu puzzles inspired by some of your previous work. These puzzles are all different protein binders but the way in which they bind is very similar. We look forward to seeing your results! If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, & 7-1 through 7-4. See the puzzle comments for more design puzzle help.

488: Experimental Exploration Puzzle 1

For this exploration puzzle, we're trying something a little different. Instead of using contact maps and awarding exploration through a multiplier, this puzzle is scored with a lower clashing importance. You'll notice you can get quite a few points from structures that would normally require stabilization. The protein itself is a re-post of CASP9 refinement puzzle 8.

486: Exploration Puzzle of 457 with Constraints

This is the exploration version of puzzle 457 - this time with constraints. Explore away from the starting structure to increase your score multiplier. Play the exploration puzzle tutorial and get started by going to [Actions]->[Contact Map]. This first round will be worth 40 points and will last 4 days.

479b: Beginner Symmetry Puzzle

(Reposted) This is the first symmetry puzzle - a small symmetric dimer. The structure is mostly correct - your job is to try and match the two subunits together so that they interface as well as possible. Your changes will be reflected in the symmetric unit. Brush up on the use of the move tool (Intro Puzzle 5-2) - you'll need it.

485: Quick Alignment Puzzle 482

This is a quick repost of Puzzle 482: Advanced Alignment Puzzle, but this time we are providing you with secondary structure predictions that are posted in the puzzle comments and included in the starting structure as well. These predictions are from the SAM-T08 server (as requested in the previous puzzle comments: http://fold.it/portal/node/991105). Check out that page for more hints and make sure you beat Intro Puzzles 6-1 through 6-3 before playing this puzzle.

481: Unsolved Nanog Transcription Factor 2

We are posting 10 more starts for the unsolved Nanog protein (while it's still fresh in your mind). Resetting the puzzle will cycle through 10 Quark server predictions that are also in the Alignment Tool so you can use partial threading. This puzzle will be up for 2 weeks and worth 175 global points! More info in the puzzle comments and blog: http://fold.it/portal/node/991003