Foldit Puzzles

450: Huge Unsolved Leishmania Parasite Protein

This one's going to be tough. Every attempt so far to solve this 244-residue protein has failed. There are no NMR models to use as starting points, so we are giving you 5 Zhang Server predictions to start from. Each time you reset the puzzle one of these 5 models will randomly be chosen. They are also in the Alignment Tool so you can use partial threading. Since this protein is so big we are giving you 20 days to work on it (for 200 global points) and we'll post as much help as we can in the puzzle comments.

456: Electron Density Puzzle 2

In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. This puzzle has been updated, since the first release of 456 was corrupt. Make sure you have the latest version of the puzzle!

455: Revisiting Puzzle 165

This is the first in a series of puzzles, where we revist older Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles. This first Revisiting Puzzle goes back to July 2009; enjoy the trip back in time!

455 (<15): Revisiting Puzzle 165

This is the first in a series of puzzles, where we revist older Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles. This first Revisiting Puzzle goes back to July 2009; enjoy the trip back in time! For players with fewer than 15 global points.

455 (<150): Revisiting Puzzle 165

This is the first in a series of puzzles, where we revist older Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles. This first Revisiting Puzzle goes back to July 2009; enjoy the trip back in time! For players with fewer than 150 global points.

452: De-novo Freestyle 13

We are giving you this currently unsolved protein as an extended chain. Use all your beta-sheet forming skills to fold it up as best as you can. The secondary structure predictions are posted in the puzzle comments, but we have included them in the starting structure as well.

454: CASP9 Refinement Puzzle 8 - Exporation Round 3

This is the third round of Exploration Puzzle 449. This round will be very short (2 days!) and will be worth 20 points. Explore away from the top solutions from rounds 1 and 2 to increase your multiplier. You can use threading to use all or part of any of these solutions, but remember, just copying all of one solution won't get you any points! Try using just part or using a previous solution as a starting point and form new contacts!

451: Unconstrained Refinement Puzzle

This puzzle has no constraints (for now) so see what you can do to improve the structure!

451 (<15): Unconstrained Refinement Puzzle

This puzzle has no constraints (for now) so see what you can do to improve the structure! For players with fewer than 15 global points.

451 (<150): Unconstrained Refinement Puzzle

This puzzle has no constraints (for now) so see what you can do to improve the structure! For players with fewer than 150 global points.