Foldit Puzzles

453: CASP9 Refinement Puzzle 8 - Exporation Round 2

This is the second round of Exploration Puzzle 449. This round will be very short (2 days!) and will be worth 20 points. Explore away from the top solutions from round 1 to increase your multiplier. You can use threading to use all or part of any of these solutions, but remember, just copying all of one solution won't get you any points! Try using just part or using a previous solution as a starting point and form new contacts!

449: CASP9 Refinement Puzzle 8 - Constraints and Exploration

We are reposting Puzzle 445b, this time as an exploration puzzle. Again there are 2 starting models (resetting the puzzle will randomly pick one). Press Q to center the structure after resetting. This puzzle will be a short round (4 days) worth 50 points. After that, we will run another round where you will get to combine the top solutions from the first round.

448: H2N2 Flu Design Puzzle 2b

Press Q to center the protein. This is a repost of Puzzle 428, but we've tweaked some parameters since the last time you've seen this protein. The goal is to design the interface of these designs so that it can bind to the H2 subtype of Influenza. Make sure you have completed the Intro Puzzle 4-5 (this is crucial to performing well on this puzzle) as well as Design Puzzles 6-1 through 6-4. This puzzle is again worth 150 global points!

447: De-novo Freestyle 12

We are giving you this currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are posted in the puzzle comments, but we have included them in the starting structure as well.

446: Quest to the Native vs Electron Density 1

We are reposting Puzzle 438: Electron Density 1, but this time as a Quest to the Native with the solved native structure as a guide. We would like to see how much easier it is to match the native compared to using the Electron Density as as guide. Press G to Align the Guide.

445b: CASP9 Refinement Puzzle 8 - Double Start with constraints

We are reposting puzzle 349: CASP9 Refinement Puzzle 8 - Double Start, because the native structure still has not been released. This time, however, we would like to see if these few constraints are helpful. Each of these models has different parts modeled better than the other one. So that you can combine information from both of them, we are giving you both models (resetting the puzzle will randomly pick one and both are in your template reserve). Press Q to center the structure after resetting.

445b (<15): CASP9 Refinement Puzzle 8 - Double Start with constraints

We are reposting puzzle 349: CASP9 Refinement Puzzle 8 - Double Start, because the native structure still has not been released. This time, however, we would like to see if these few constraints are helpful. Each of these models has different parts modeled better than the other one. So that you can combine information from both of them, we are giving you both models (resetting the puzzle will randomly pick one and both are in your template reserve). Press Q to center the structure after resetting. For players with fewer than 15 global points.

445b (<150): CASP9 Refinement Puzzle 8 - Double Start with constraints

We are reposting puzzle 349: CASP9 Refinement Puzzle 8 - Double Start, because the native structure still has not been released. This time, however, we would like to see if these few constraints are helpful. Each of these models has different parts modeled better than the other one. So that you can combine information from both of them, we are giving you both models (resetting the puzzle will randomly pick one and both are in your template reserve). Press Q to center the structure after resetting. For players with fewer than 150 global points.

445: CASP9 Refinement Puzzle 8 - Double Start with constraints

This puzzle had an error in it and has been reposted as Puzzle 445b.

445 (<15): CASP9 Refinement Puzzle 8 - Double Start with constraints

This puzzle had an error in it and has been reposted as Puzzle 445b. For players with fewer than 15 global points.