Foldit Puzzles

435: Slightly Constrained Exploration Puzzle

An exploration puzzle with few constraints. Explore away from the starting structure to increase your score multiplier. You can see where to explore by going to [Actions]>[Contact Map].

433: Slightly Constrained Puzzle

This puzzle has very few constraints. We would like to see how well you can refine this non-Rosetta-generated model.

433 (<15): Slightly Constrained Puzzle

This puzzle has very few constraints. We would like to see how well you can refine this non-Rosetta-generated model. For players with fewer than 15 global points.

433 (<150): Slightly Constrained Puzzle

This puzzle has very few constraints. We would like to see how well you can refine this non-Rosetta-generated model. For players with fewer than 150 global points.

432: De-novo Freestyle 8

We are giving you this currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are posted in the puzzle comments, but we have included them in the starting structure as well.

431: Multi-Start Nuclear Ribonucleoprotein

We are giving you 5 server models for this currently unsolved protein. Each time you reset the puzzle one of these 5 Zhang server predictions will randomly be chosen. They are also in the Alignment Tool so you can use partial threading and well as an extended chain. We would like to see how well you can refine these models that were not generated using Rosetta.

431 (<15): Multi-Start Nuclear Ribonucleoprotein

We are giving you 5 server models for this currently unsolved protein. Each time you reset the puzzle one of these 5 Zhang server predictions will randomly be chosen. They are also in the Alignment Tool so you can use partial threading and well as an extended chain. We would like to see how well you can refine these models that were not generated using Rosetta. For players with fewer than 15 global points.

431 (<150): Multi-Start Nuclear Ribonucleoprotein

We are giving you 5 server models for this currently unsolved protein. Each time you reset the puzzle one of these 5 Zhang server predictions will randomly be chosen. They are also in the Alignment Tool so you can use partial threading and well as an extended chain. We would like to see how well you can refine these models that were not generated using Rosetta. For players with fewer than 150 global points.

430: Easy Mini Freestyle Puzzle 1b

We are giving you this currently unsolved short protein as an extended chain one last time. This time we are providing you with secondary structure predictions (available in the puzzle comments) that are pre-loaded in the puzzle. This puzzle will be worth 75 global points.

429: Heavily Constrained Puzzle

You might recognize this protein from the last exploration puzzle. We know it is very heavily constrained, but we want to see what players come up with when it is run as a normal puzzle.