Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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The results from the first Flu puzzle were very interesting and we would like to give you a different subtype of the H2N2 Japan 1956 Influenza virus. The goal is to design the interface of these designs so that it can bind to the H2 subtype of Influenza. This puzzle is also worth 150 global points! If you are new to Foldit, make sure you have completed the Intro Puzzle 4-5 and Design Puzzles 6-1 through 6-4 and read the blog for more info about these Flu puzzles: fold.it/portal/blog
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Closed
since
almost 15 years
ago
We are giving it to you this currently unsolved short protein as an extended chain. Because it's only 48 residues we're going to post it twice: first with no secondary structure predictions for 4 days and then another 4 days with it. Each puzzle will be worth 75 global points.
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Closed
since
almost 15 years
ago
We're going back to the previous exploration puzzle, this time with constraints. You will find that the unconstrained portions of the protein are the same portions that are available for exploration on the Contact Map. We've tried to reduce the number of constraints this time, in order to improve performance. Get started by going to [Actions]->[Contact Map] and gaining contacts to increase your score multiplier.
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This is the first of the many new exciting Flu puzzles David Baker mentioned in his blogpost. Our lab designed against the H1N1 subtype of the virus, but a related subtype with pandemic potential, H2N2, has different sidechains in this region that perturb binding. The goal is to design the interface of these designs so that it can bind to the H2 subtype of Influenza. This puzzle is worth 150 global points! If you are new to Foldit, make sure you have completed the Intro Puzzle 4-5 and Design Puzzles 6-1 through 6-4.
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Closed
since
almost 15 years
ago
Increase your score multiplier by exploring away from the starting structure. We've introduced constraints as well, so you'll have to explore while preserving certain parts of the structure. You can use the Contact Map to figure out where to explore (Available in [Actions]->[Contact Map]). The more contacts in white areas you get, the higher your multiplier.
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This puzzle had an error in it and has been reposted as Puzzle 425, sorry for the trouble with this.
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We are giving you this currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are posted in the puzzle comments, but we have included them in the starting structure as well.
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Closed
since
almost 15 years
ago
This unsolved protein has 10 close homologs that we are giving to you as templates. Try them out using the alignment tool. Since you have 10 templates to try out we're giving you an extra day to work on this puzzle. Make sure to try Intro Puzzles 5-1 to 5-3 if you aren't familiar with the Alignment Tool. Alignment Tool help can be found here: http://foldit.wikia.com/wiki/Alignment_Tool.
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This unsolved protein has 10 close homologs that we are giving to you as templates. Try them out using the alignment tool. Make sure to try Intro Puzzles 5-1 to 5-3 if you aren't familiar with the Alignment Tool. Alignment Tool help can be found here: http://foldit.wikia.com/wiki/Alignment_Tool. Since you have 10 templates to try out we're giving you an extra day. For players with fewer than 15 global points.
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This unsolved protein has 10 close homologs that we are giving to you as templates. Try them out using the alignment tool. Make sure to try Intro Puzzles 5-1 to 5-3 if you aren't familiar with the Alignment Tool. Alignment Tool help can be found here: http://foldit.wikia.com/wiki/Alignment_Tool. Since you have 10 templates to try out we're giving you an extra day. For players with fewer than 150 global points.