Foldit Puzzles

420: Mini Protein Puzzle 2: Ebola Ligand

Here is another small protein domain with a ligand (a fragment of an Ebola protein), but this time we are allowing flexibility in the ligand. We would recommend freezing the ligand initially, but will let you figure out the best way to accomodate it. More details about this miniprotein in the puzzle comments.

420 (<15): Mini Protein Puzzle 2: Ebola Ligand

Here is another small protein domain with a ligand (a fragment of an Ebola protein), but this time we are allowing flexibility in the ligand. We would recommend freezing the ligand initially, but will let you figure out the best way to accomodate it. For players with fewer than 15 global points.

420 (<150): Mini Protein Puzzle 2: Ebola Ligand

Here is another small protein domain with a ligand (a fragment of an Ebola protein), but this time we are allowing flexibility in the ligand. We would recommend freezing the ligand initially, but will let you figure out the best way to accomodate it. For players with fewer than 150 global points.

419: New Style Exploration Puzzle Round 3

The third round of the new style exploration puzzle. This time we're giving you more information about which areas to explore. You're only awarded for exploring in these areas. Use the Contact Map to figure out where these areas are. To start, go to [Actions]->[Contact Map]. You should also be able to load in your solutions from previous rounds.

418: Back Me Up 2

We designed a helix to contact the ligand, but the helix needs some back up to stay in place. You can mutate many of the residues to create a more stable configuration and make a more active catalyst (ie create a Helix-Loop-Helix). This puzzle will be worth 125 global points! if you are new to Foldit, make sure you have completed the Introductory Design Puzzles (6-1 through 6-4)

417: Easy Alignment Puzzle

This unsolved protein has 2 close homologs that we are giving to you as templates. Try them out using the alignment tool. Make sure to try Intro Puzzles 5-1 to 5-3 if you aren't familiar with the Alignment Tool. Alignment Tool help can be found here: http://foldit.wikia.com/wiki/Alignment_Tool.

415: Mini Protein Puzzle 1

This tiny domain is an independently-folding piece of a larger protein involved in Brain function. We haven't had much luck arriving at low-energy native-like structures of these small domains using Rosetta, so we are hoping you can help us! More details in the puzzle comments.

415 (<15): Mini Protein Puzzle 1

This tiny domain is an independently-folding piece of a larger protein involved in Brain function. We haven't had much luck arriving at low-energy native-like structures of these small domains using Rosetta, so we are hoping you can help us! For players with fewer than 15 global points.

415 (<150): Mini Protein Puzzle 1

This tiny domain is an independently-folding piece of a larger protein involved in Brain function. We haven't had much luck arriving at low-energy native-like structures of these small domains using Rosetta, so we are hoping you can help us! For players with fewer than 150 global points.

416: New Style Exploration Puzzle Round 2

The second round of the new style exploration puzzle. Round 1 showed that people explored too much, so we've made adjustments to make reaching the maximum multiplier easier. Remember that these puzzles are a work in progress, and it will take some time to get everything fine tuned. Thanks for your patience!