Foldit Puzzles

877: Revisiting Puzzle 117: Transport Mutant

This is a throwback puzzle to the early days of Foldit. This is a small protein participates in electron transfer reactions in the cell. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

876: De-novo Freestyle 38: Low Power

In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

875: De-novo Freestyle 37: Predicted Contacts

This is a follow-up puzzle for Puzzles 867 and 872, now with Predicted Contacts to help guide your folding. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). You will notice that different contacts are shown in different shades of blue, with darker blue contacts indicating stronger predictions. Please ignore the contact multiplier in this puzzle, which should remain at 1.00 for all folded solutions; in this puzzle, satisfied contacts contribute directly to the Stability score. Note that for this puzzle, you will NOT be able to load in your manual saves from previous rounds.

875: De-novo Freestyle 37: Predicted Contacts

This is a follow-up puzzle for Puzzles 867 and 872, now with Predicted Contacts to help guide your folding. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). You will notice that different contacts are shown in different shades of blue, with darker blue contacts indicating stronger predictions. Please ignore the contact multiplier in this puzzle, which should remain at 1.00 for all folded solutions; in this puzzle, satisfied contacts contribute directly to the Stability score. Note that for this puzzle, you will NOT be able to load in your manual saves from previous rounds.

875b: De-novo Freestyle 37: Predicted Contacts

NOTE: Due to a hiccup earlier today, two duplicate 875 puzzles were previously posted. Both of those puzzles have now been closed, but you may load in solutions from either of those puzzles.

873: Revisiting Puzzle 115: Exocyst

This is a throwback puzzle to the early days of Foldit. This protein is involved in the process of exocytosis, transporting proteins to the cell membrane or extracellular areas. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

1659: Integrin Antagonist Binder Design

Help design a protein binder for cancer therapy!

874: 85 Residue Monomer Design: Round 2

This is a repost of Puzzle 866, now with the Fragment Filter and a slight change to the residue Reference score to discourage Alanine residues in the protein core. Load in your solutions from Puzzle 866 and try to improve any bad fragments or regions rich in Alanine! NOTE: If you did not manually save a solution in puzzle 866, you can go back to 866, manually save it, and the solution should appear in your manual saves for this puzzle.

871: De-novo Freestyle 36: Predicted Contacts

This is a follow-up puzzle for Puzzles 864 and 868, now with Predicted Contacts to help guide your folding. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). You will notice that different contacts are shown in different shades of blue, with darker blue contacts indicating stronger predictions. Please ignore the contact multiplier in this puzzle, which should remain at 1.00 for all folded solutions; in this puzzle, satisfied contacts contribute directly to the Stability score. Note that for this puzzle, you will NOT be able to load in your manual saves from previous rounds.

871b: De-novo Freestyle 36: Predicted Contacts

This is a follow-up puzzle for Puzzles 864 and 868, now with Predicted Contacts to help guide your folding. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). You will notice that different contacts are shown in different shades of blue, with darker blue contacts indicating stronger predictions. Please ignore the contact multiplier in this puzzle, which should remain at 1.00 for all folded solutions; in this puzzle, satisfied contacts contribute directly to the Stability score. Note that for this puzzle, you will NOT be able to load in your manual saves from previous rounds.