Foldit Puzzles

882: Revisiting Puzzle 124: PDZ Domain

This is a throwback puzzle to the early days of Foldit. This domain is a component of many proteins involved in cell signaling. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

879: Ebola Binder Design with Disulfides

This is a design puzzle with 37 residues, near the interface of a target glycoprotein from the Ebola virus. At the binding site of the Ebola protein, there is already a helix designed by scientists in the Baker Lab, but the helix will not fold up by itself! Build a scaffold around the starting design that will fold up properly and stabilize the binding helix! There are strong constraints to keep the binding helix in place, and you may not mutate residues at the interface. You may not add additional residues to the design, but you may delete residues from one end of the design and reinsert them at the other end. You will receive an (extremely) large bonus for making up to 2 disulfide bonds. Remember to share your favorite designs using the Share with Scientist tool, even if those are not your best-scoring solutions!

880: De-novo Freestyle 38: High Power

This is a repost of Puzzle 876, now with the High Wiggle Power option enabled. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. Note that players will NOT be able to load in previous solutions from Puzzle 876.

878: 95 Residue Monomer Design

This is a single-chain design puzzle with 95 residues. There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The High Wiggle Power option has been disabled, and the Fragment Filter has been omitted, although these tools may return in a followup refinement round. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!

877: Revisiting Puzzle 117: Transport Mutant

This is a throwback puzzle to the early days of Foldit. This is a small protein participates in electron transfer reactions in the cell. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

876: De-novo Freestyle 38: Low Power

In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

875: De-novo Freestyle 37: Predicted Contacts

This is a follow-up puzzle for Puzzles 867 and 872, now with Predicted Contacts to help guide your folding. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). You will notice that different contacts are shown in different shades of blue, with darker blue contacts indicating stronger predictions. Please ignore the contact multiplier in this puzzle, which should remain at 1.00 for all folded solutions; in this puzzle, satisfied contacts contribute directly to the Stability score. Note that for this puzzle, you will NOT be able to load in your manual saves from previous rounds.

875: De-novo Freestyle 37: Predicted Contacts

This is a follow-up puzzle for Puzzles 867 and 872, now with Predicted Contacts to help guide your folding. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). You will notice that different contacts are shown in different shades of blue, with darker blue contacts indicating stronger predictions. Please ignore the contact multiplier in this puzzle, which should remain at 1.00 for all folded solutions; in this puzzle, satisfied contacts contribute directly to the Stability score. Note that for this puzzle, you will NOT be able to load in your manual saves from previous rounds.

875b: De-novo Freestyle 37: Predicted Contacts

NOTE: Due to a hiccup earlier today, two duplicate 875 puzzles were previously posted. Both of those puzzles have now been closed, but you may load in solutions from either of those puzzles.

873: Revisiting Puzzle 115: Exocyst

This is a throwback puzzle to the early days of Foldit. This protein is involved in the process of exocytosis, transporting proteins to the cell membrane or extracellular areas. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.