Foldit Puzzles

1659: Integrin Antagonist Binder Design

Help design a protein binder for cancer therapy!

874: 85 Residue Monomer Design: Round 2

This is a repost of Puzzle 866, now with the Fragment Filter and a slight change to the residue Reference score to discourage Alanine residues in the protein core. Load in your solutions from Puzzle 866 and try to improve any bad fragments or regions rich in Alanine! NOTE: If you did not manually save a solution in puzzle 866, you can go back to 866, manually save it, and the solution should appear in your manual saves for this puzzle.

871: De-novo Freestyle 36: Predicted Contacts

This is a follow-up puzzle for Puzzles 864 and 868, now with Predicted Contacts to help guide your folding. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). You will notice that different contacts are shown in different shades of blue, with darker blue contacts indicating stronger predictions. Please ignore the contact multiplier in this puzzle, which should remain at 1.00 for all folded solutions; in this puzzle, satisfied contacts contribute directly to the Stability score. Note that for this puzzle, you will NOT be able to load in your manual saves from previous rounds.

871b: De-novo Freestyle 36: Predicted Contacts

This is a follow-up puzzle for Puzzles 864 and 868, now with Predicted Contacts to help guide your folding. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). You will notice that different contacts are shown in different shades of blue, with darker blue contacts indicating stronger predictions. Please ignore the contact multiplier in this puzzle, which should remain at 1.00 for all folded solutions; in this puzzle, satisfied contacts contribute directly to the Stability score. Note that for this puzzle, you will NOT be able to load in your manual saves from previous rounds.

872: De-novo Freestyle 37: High Power

This is a repost of Puzzle 867, now with the High Wiggle Power option enabled. This puzzle will only be open for a few days, and you may load in solutions from Puzzle 867. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. NOTE: If you did not manually save a solution in puzzle 867, you can go back to 867, manually save it, and the solution should appear in your manual saves for this puzzle.

870: 75 Residue Monomer Design: Strand-Locked

This is a single-chain design puzzle with 75 residues, and four of the residues are locked into a beta-strand conformation. There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 25% of the residues are buried in the core of your design. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!

869: Revisiting Puzzle 114: Black Mamba

This is a throwback puzzle to the early days of Foldit. This protein is a toxin found in the intestines of the African black mamba. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

867: De-novo Freestyle 37: Low Power

In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. After this puzzle expires, the puzzle may be reposted for a brief period with the High Wiggle Power option enabled, and you will be able to load in solutions from this puzzle. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

868: De-novo Freestyle 36: High Power

This is a repost of Puzzle 864, now with the High Wiggle Power option enabled. This puzzle will only be open for a few days, and you may load in solutions from Puzzle 864. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. NOTE: If you did not manually save a solution in puzzle 864, you can go back to 864, manually save it, and the solution should appear in your manual saves for this puzzle.

866: 85 Residue Monomer Design

This is a single-chain design puzzle with 85 residues. There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The High Wiggle Power option has been disabled, and the Fragment Filter has been omitted, although these tools may return in a followup refinement round. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!