Foldit Puzzles

859: Attack of the glycines!

Glycine is an unusual amino acid. Of the 20 standard amino acids, it is the only one that does not have handedness: all others cannot be superimposed on their mirror images, but glycine can. This means that glycine is just as happy forming one structure -- (an ordinary, right-handed alpha-helix, for example) as it is forming the mirror image structure (a backwards, left-handed helix, for example). This extra flexibility and the competition with other, energetically equivalent states makes it hard to lock glycine in one conformation, meaning that glycine tends to disrupt secondary structure.

858: Revisiting Puzzle 111: Mouse

This is a throwback puzzle to the early days of Foldit. This protein is found in the nucleus of mice cells and functions in the DNA binding process. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

857: De-novo Freestyle 35: Hand-folding Round

We are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

854: 75 Residue Monomer Design

This is a single-chain design puzzle with 75 residues. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment Filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!

855: Revisiting Puzzle 110: Turkey

This is a throwback puzzle to the early days of Foldit. This is a portion of a troponin protein found in the skeletal muscle of turkeys. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

853: De-novo Freestyle 34: Round 2

This is Round 2 for Puzzle 849b. You will be able to load in your manual saves from 849b and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 849b, you can go back to 849b, manually save it, and the solution should appear in your manual saves for this puzzle.

856: Trimer Interface Redesign: Round 3

This is the third round in a series of interface redesign puzzles with increasing tolerance for buried blue, polar residues. Try to redesign a more polar interface between the symmetric subunits of this protein! This symmetric trimer was originally designed by Museka in Puzzle 742. See Puzzle 851 for more information. Due to some bugs apparent in previous rounds of this puzzle, players will NOT be able to load in solutions from Puzzles 851 or 852.

852: Trimer Interface Redesign: Round 2

This is the second round in a series of interface redesign puzzles with increasing tolerance for buried blue, polar residues. Try to redesign a more polar interface between the symmetric subunits of this protein! This symmetric trimer was originally designed by Museka in Puzzle 742. See Puzzle 851 for more information. You may load in previous solutions from Puzzle 851.

850: Revisiting Puzzle 109: Pumpkin

This is a throwback puzzle to the early days of Foldit. This is a trypsin inhibitor in pumpkins. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

849a: De-novo Freestyle 34 Mutant: Hand-folding Round

This is a shortened version of Puzzle 849b, and was originally posted in error. Since many players had invested several hours into this hand-folding puzzle before the error was caught, we are re-opening the puzzle.