Foldit Puzzles

855: Revisiting Puzzle 110: Turkey

This is a throwback puzzle to the early days of Foldit. This is a portion of a troponin protein found in the skeletal muscle of turkeys. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

853: De-novo Freestyle 34: Round 2

This is Round 2 for Puzzle 849b. You will be able to load in your manual saves from 849b and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 849b, you can go back to 849b, manually save it, and the solution should appear in your manual saves for this puzzle.

856: Trimer Interface Redesign: Round 3

This is the third round in a series of interface redesign puzzles with increasing tolerance for buried blue, polar residues. Try to redesign a more polar interface between the symmetric subunits of this protein! This symmetric trimer was originally designed by Museka in Puzzle 742. See Puzzle 851 for more information. Due to some bugs apparent in previous rounds of this puzzle, players will NOT be able to load in solutions from Puzzles 851 or 852.

852: Trimer Interface Redesign: Round 2

This is the second round in a series of interface redesign puzzles with increasing tolerance for buried blue, polar residues. Try to redesign a more polar interface between the symmetric subunits of this protein! This symmetric trimer was originally designed by Museka in Puzzle 742. See Puzzle 851 for more information. You may load in previous solutions from Puzzle 851.

850: Revisiting Puzzle 109: Pumpkin

This is a throwback puzzle to the early days of Foldit. This is a trypsin inhibitor in pumpkins. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

849a: De-novo Freestyle 34 Mutant: Hand-folding Round

This is a shortened version of Puzzle 849b, and was originally posted in error. Since many players had invested several hours into this hand-folding puzzle before the error was caught, we are re-opening the puzzle.

849b: De-novo Freestyle 34: Hand-folding Round

This is a corrected repost of Puzzle 849a. We are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

851: Trimer Interface Redesign: Round 1

This is a symmetric trimer that was originally designed by Museka in Puzzle 742. We'd like you to try to redesign the interface between the subunits to include a couple hydrogen bonds and blue, polar contacts amongst all the orange hydrophobic residues that are in the starting structure. Baker Lab scientists have cloned and expressed this protein in E. coli, but instead of aligning into well-ordered trimers, it appears to form disordered aggregates in solution. We think that this can be corrected by reducing the hydrophobic surface of the monomer subunit. Because this is uncharted territory for our score function, we're starting out with a pretty low tolerance for buried polar residues. We plan to post several of these puzzles in series—each with increased tolerance for a polar interface.

848: Revisiting Puzzle 97: Pig

This is a throwback puzzle to the early days of Foldit. This saposin protein from pig serves as an activator for lipid-desolving enzymes. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

847: 65 Residue Dimer Design

This is a symmetric dimer design puzzle with 65 residues. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment Filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!