Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed since about 12 years agoWe would like to design a peptide to treat the Ebola virus. This puzzle is a hotspot discovery puzzle, meaning that we would like you to find a good place in which to fit a small peptide "stub" in a particular hydrophobic binding pocket on the Ebola virus glycoprotein. We will then use the best stub placements as starting points for designing a larger molecule. Blocking this pocket on the Ebola glycoprotein will prevent the glycoprotein from binding to proteins on host cells, and should thereby block viral entry into host cells. We're starting you with a tryptophan, but you can mutate the stub residues to whatever you like. Remember that you can share interesting designs with the scientists, regardless your score!
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Closed since about 12 years ago
This is a repost of a De-novo Freestyle puzzle we ran in October of 2013. Your solutions for this puzzle will help us evaluate some features of the recent Foldit updates. Players will NOT be able to load in solutions from Puzzle 786.
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Closed since over 12 years ago
This is a follow-up to Puzzle 837. We're still calibrating some parameters of the newest score function, and this puzzle has been slightly modified to encourage better core packing. You may notice that Alanine residues do not score as well as in the previous puzzle. Load in your solutions from Puzzle 837 and mutate the core residues to improve your score!
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Closed since over 12 years ago
843: CASP ROLL Target R0046: Server Models
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL843: CASP ROLL Target R0046: Server Models
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLThis is the same CASP ROLL target as in Puzzle 840, now with server predictions! Resetting the puzzle will cycle through 3 different server predictions and they are available in the Alignment Tool so you can use partial threading between them. Please try out each start, as the topology that initially scores poorly may actually be the closest to the native and will eventually score better than everything else.
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Closed since over 12 years ago
This is a throwback puzzle to the early days of Foldit. Collagen is one of the most abundant proteins in mammals. It is the main protein of connective tissue in animals. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
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Closed since over 12 years ago
This is Round 2 for Puzzle 838. You will be able to load in your manual saves from 838 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 838, you can go back to 838, manually save it, and the solution should appear in your manual saves for this puzzle.
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Closed since over 12 years ago
840: CASP ROLL Target R0046
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL840: CASP ROLL Target R0046
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLThis unsolved CASP ROLL target has 128 residues. After this puzzle closes, there will be one more round with server predictions. See the puzzle comments for secondary structure predictions.
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Closed since over 12 years ago
This is a throwback puzzle to the early days of Foldit. A protein that is involved in the immune and inflammatory response of the mouse. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
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Closed since over 12 years ago
This is a single-chain design puzzle with 65 residues. This puzzle is very similar to Puzzle 817, and will help us benchmark the recent Foldit update. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment Filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!
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Closed since over 12 years ago
838: De-novo Freestyle 33: Hand-folding Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding838: De-novo Freestyle 33: Hand-folding Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-FoldingWe are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.