Foldit Puzzles

840: CASP ROLL Target R0046

This unsolved CASP ROLL target has 128 residues. After this puzzle closes, there will be one more round with server predictions. See the puzzle comments for secondary structure predictions.

839: Revisited Puzzle 95: Chicken

This is a throwback puzzle to the early days of Foldit. A protein that is involved in the immune and inflammatory response of the mouse. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

837: 65 Residue Monomer Design

This is a single-chain design puzzle with 65 residues. This puzzle is very similar to Puzzle 817, and will help us benchmark the recent Foldit update. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment Filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!

838: De-novo Freestyle 33: Hand-folding Round

We are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

836: Revisiting Puzzle 94: Mouse

EARLY EXPIRATION NOTICE:

835: SOD1 Hotspot

Mutations in the gene encoding the SOD1 protein cause a subset of cases of amyotrophic lateral sclerosis, or Lou Gehrig's disease. There is some evidence that the two SOD1 subunits in the dimer separate as part of the aggregation process, so a molecule that is able to "glue" the dimer together could help to slow or halt the molecular events that lead to the disease. As a starting point for designing such a "glue", we'd like you to find good places at the interface between the SOD1 subunits to place a small, three-residue fragment. In designing the sequence of this fragment, keep in mind that hydrophobic interactions (interactions with orange residues) are much more likely to give high affinity and specificity than polar interactions (interactions with blue residues), so we recommend focusing on placing hydrophobic side-chains in the cleft between the subunits. Good luck!

831: Abeta Loop Closure B

This puzzle builds on a piecewise design solution from Puzzle 808. Build loops to close the cutpoints between secondary structure elements to create an Abeta-binding protein! The two starting structures were derived from a single solution by gitwut and martinzblavy, but have different loop arrangements. Reset the puzzle to cycle through both starting structures. See the puzzle comments for more details. This puzzle will be open for two weeks.

834: Revisiting Puzzle 93: Spider Toxin

This is a throwback puzzle to the early days of Foldit. This protein is from a neurotoxin found in the funnel spider. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

833: De-novo Freestyle 32: Round 2

This is Round 2 for Puzzle 830. You will be able to load in your manual saves from 830 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 830, you can go back to 830, manually save it, and the solution should appear in your manual saves for this puzzle.

832: Revisiting Puzzle 92: Bacteria

This is a throwback puzzle to the early days of Foldit. This protein comes from the bacteria Escherichia coli. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.