Foldit Puzzles

830: De-novo Freestyle 32: Hand-folding Round

We are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

829: Revisiting Puzzle 91: Viral Protein

This is a throwback puzzle to the early days of Foldit. This protein is used by viruses to penetrate the membranes of cells. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

828: Abeta Loop Closure A

This puzzle builds on a piecewise design solution from Puzzle 808. Build loops to close the cutpoints between secondary structure elements to create an Abeta-binding protein! The two starting structures were derived from a single solution by Grom and Rita_Gat, but have different loop arrangements. Reset the puzzle to cycle through both starting structures. See the puzzle comments for more details. This puzzle will be open for two weeks.

826: Unsolved Electron Density: Round 3

We are reposting Unsolved Electron Density Puzzle 816, but this time with an improved electron density cloud. You will be able to load in your manual saves from 813/816 and use them as a starting point here. NOTE: If you did not manually save a solution in puzzle 813 or 816, you can go back and manually save it, and the solution should appear in your manual saves for this puzzle.

825: Holiday Snowflake Design

This is a symmetric hexamer design puzzle with 70 residues; there will be six symmetric chains to manage. This puzzle includes 3 filters: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well; the Core Exists filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment Score filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab.

824: Revisiting Puzzle 90: Heliomicin

This is a throwback puzzle to the early days of Foldit. Heliomicin is a type of anti-fungal protein. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

827: CASP ROLL Target R0044: Server Models

This is the same CASP ROLL target as in Puzzle 823, now with server predictions! Use the Alignment Tool to thread the target sequence onto 5 server predictions. Please try alignments to each model, as the topology that initially scores poorly may actually be the closest to the native and will eventually score better than everything else.

823: Large CASP ROLL Target R0044

This unsolved CASP ROLL target is larger than most Foldit puzzles, at 204 residues. There are no homologs, so we are starting you from an extended chain. After this puzzle closes, there will be one more round with server predictions. See the puzzle comments for secondary structure predictions.

822: CASP ROLL Target R0043: Server Models

This is the same CASP ROLL target as in Puzzle 819, now with server predictions! Resetting the puzzle will cycle through 5 different server predictions and they are available in the Alignment Tool so you can use partial threading between them. Please try out each start, as the topology that initially scores poorly may actually be the closest to the native and will eventually score better than everything else.

821: Revisiting Puzzle 89: Cow Eye

This is a throwback puzzle to the early days of Foldit.This protein is found in Gamma B Crystallin molecules, which are a structural molecule in the eye lens of the cow. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.