Foldit Puzzles

820: PduN Microcompartment Protein

The PduN protein is thought to self-assemble into symmetric oligomers that form microcompartments in bacteria. The structure of PduN is unknown, although there are several homologous proteins with published structures, which are provided as templates in this puzzle. Use the Alignment Tool to overlay the PduN residues with the templates and find the best-scoring structure of PduN! See the new blog post for more information about this protein.

819: CASP ROLL Target R0043

This unsolved CASP ROLL target has 163 residues. There are no homologs, so we are starting you from an extended chain. After this puzzle closes, there will be one more round with server predictions. See the puzzle comments for secondary structure predictions.

818: Revisiting Puzzle 88: Monocyte

This is a throwback puzzle to the early days of Foldit. This protein is taken from a monocyte. A monocyte is a type of leukocyte, part of the human immune system. One of its primary jobs is to help replenish other immune system cells. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

817: 65 Residue Monomer Design

This is a single-chain design puzzle with 65 residues. It uses the new Fragment Filter and Remix Tool to help you design proteins that are likely to fold up in the lab. There are 2 other filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!

816: Unsolved Electron Density: Round 2

This is Round 2 for Unsolved Electron Density Puzzle 813. You will be able to load in your manual saves from 813 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 813, you can go back to 813, manually save it, and the solution should appear in your manual saves for this puzzle.

815: Revisiting Puzzle 87: Zinc Binding Protein

This is a throwback puzzle to the early days of Foldit. A type of metal binding protein. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

814: Ferredoxin Pentamer Design: Round 2 (without fragment filter)

This is a repost of Puzzle 805, with a few important changes. The protein backbone is no longer frozen, but there is an RMSD condition on most of the residues, to maintain the ferredoxin-like fold. This protein chain includes an extra helix at the N- or C-terminus, although you can redesign it to whatever shape you like—this helix is ignored by the RMSD condition. Reset the puzzle to alternate between the extended N- and C-terminus versions. This puzzle also includes a Residue IE filter, which monitors that all PHE, TYR, and TRP residues are scoring well.

814: Ferredoxin Pentamer Design: Round 2

This is a repost of Puzzle 805, with a few important changes. First of all, this puzzle is debuting the new Fragment Filter and Remix Tool to help you design proteins that are likely to fold up in the lab. The protein backbone is no longer frozen, but there is an RMSD condition on most of the residues, to maintain the ferredoxin-like fold. This protein chain includes an extra helix at the N- or C-terminus, although you can redesign it to whatever shape you like—this helix is ignored by the RMSD condition. Reset the puzzle to alternate between the extended N- and C-terminus versions. This puzzle also includes a Residue IE filter, which monitors that all PHE, TYR, and TRP residues are scoring well.

813: Unsolved Electron Density: Hand-folding Round

The Baker Lab and its collaborators have been unable to solve the crystal structure of this protein. The automated methods have been able to generate a model that fits part of the density, but we need your help to get the rest of the structure to fit the remaining density. We're posting this one in 2 rounds, only GUI scripts are allowed and sharing has been disabled for this round. You'll be able to load in your solutions from this puzzle and use scripting and sharing in the next round. Please help us solve the structure of this protein!

812: Revisiting Puzzle 86: Nematode

This is a throwback puzzle to the early days of Foldit. This protein is an anticoagulant, meaning it is used to clot blood. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.