Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed since over 12 years agoThis is a symmetric hexamer design puzzle with 70 residues; there will be six symmetric chains to manage. This puzzle includes 3 filters: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well; the Core Exists filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment Score filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab.
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Closed since over 12 years ago
This is a throwback puzzle to the early days of Foldit. Heliomicin is a type of anti-fungal protein. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
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Closed since over 12 years ago
827: CASP ROLL Target R0044: Server Models
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL827: CASP ROLL Target R0044: Server Models
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLThis is the same CASP ROLL target as in Puzzle 823, now with server predictions! Use the Alignment Tool to thread the target sequence onto 5 server predictions. Please try alignments to each model, as the topology that initially scores poorly may actually be the closest to the native and will eventually score better than everything else.
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Closed since over 12 years ago
823: Large CASP ROLL Target R0044
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL823: Large CASP ROLL Target R0044
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLThis unsolved CASP ROLL target is larger than most Foldit puzzles, at 204 residues. There are no homologs, so we are starting you from an extended chain. After this puzzle closes, there will be one more round with server predictions. See the puzzle comments for secondary structure predictions.
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Closed since over 12 years ago
822: CASP ROLL Target R0043: Server Models
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL822: CASP ROLL Target R0043: Server Models
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLThis is the same CASP ROLL target as in Puzzle 819, now with server predictions! Resetting the puzzle will cycle through 5 different server predictions and they are available in the Alignment Tool so you can use partial threading between them. Please try out each start, as the topology that initially scores poorly may actually be the closest to the native and will eventually score better than everything else.
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Closed since over 12 years ago
This is a throwback puzzle to the early days of Foldit.This protein is found in Gamma B Crystallin molecules, which are a structural molecule in the eye lens of the cow. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
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Closed since over 12 years ago
The PduN protein is thought to self-assemble into symmetric oligomers that form microcompartments in bacteria. The structure of PduN is unknown, although there are several homologous proteins with published structures, which are provided as templates in this puzzle. Use the Alignment Tool to overlay the PduN residues with the templates and find the best-scoring structure of PduN! See the new blog post for more information about this protein.
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Closed since over 12 years ago
819: CASP ROLL Target R0043
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL819: CASP ROLL Target R0043
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLThis unsolved CASP ROLL target has 163 residues. There are no homologs, so we are starting you from an extended chain. After this puzzle closes, there will be one more round with server predictions. See the puzzle comments for secondary structure predictions.
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Closed since over 12 years ago
This is a throwback puzzle to the early days of Foldit. This protein is taken from a monocyte. A monocyte is a type of leukocyte, part of the human immune system. One of its primary jobs is to help replenish other immune system cells. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
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Closed since over 12 years ago
This is a single-chain design puzzle with 65 residues. It uses the new Fragment Filter and Remix Tool to help you design proteins that are likely to fold up in the lab. There are 2 other filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!