Foldit Puzzles

698 (<150): Human cancer protein interaction network target

The solution structure of this dead ringer-like protein has already been solved using NMR, but the crystal structure has yet to be released. We are giving you all 20 models from the NMR ensemble. Every time you reset the puzzle it will cycle through these 20 structures and they are available in the Alignment Tool so you can use partial threading between them. We look forward to seeing how close to the crystal structure you are able to get! For players with fewer than 150 global points.

695: 70 Residue Trimer [deprecated]

This is a 70 residue symmetric trimer design puzzle; there will be three symmetric chains to manage. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blogpost about this: http://fold.it/portal/node/993871

696: Revisiting Puzzle 481

We are revisiting old Foldit puzzles so we can compare results to

693: Hand-Folding De-novo Freestyle 22

We are giving you another currently unsolved protein as an extended chain, but this time only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

691: 60 Residue Tetramer

This is a 60 residue symmetric tetramer design puzzle; there will be four symmetric chains to manage. This particular type of symmetry is a ring (C4) symmetry. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blogpost about this: http://fold.it/portal/node/993871

694: CASP T0711 Disulfide Repost Round 2

This is Round 2 for Puzzle 689. You will be able to load in your manual saves from 689 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 689, you can go back to 689, manually save it, and the solution should appear in your manual saves for this puzzle.

690: 76 Residue Dimer

This is a 76 residue symmetric dimer design puzzle. You will be able to load in your monomer solutions from "687: 76 Residue Monomer Repost".

692b: Refinement of Puzzle 671 Open Phase

This is Round 2 for Puzzle 685. You will be able to load in your manual saves from 685 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools, or start from scratch! NOTE: If you did not manually save a solution in puzzle 685, you can go back to 685, manually save it, and the solution should appear in your manual saves for this puzzle. Manual saves from 692 can also be loaded.

689b: Hand-Folding CASP10 T0711 Repost

We are reposting this 33 residue CASP10 target to try out the new Disulfide Count Score Filter. Only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. We are again giving you the top-predicted templates from 3 different alignment programs. More details about this CASP target are in the puzzle comments.

689: (Old) Hand-Folding CASP10 T0711 Repost

This puzzle has been reposted. Please use the new version of this puzzle, 689b. You may load your MANUAL saves into the new puzzle. We apologize for any inconvenience.