Foldit Puzzles

702: Second Sepsis Puzzle Round 2

This is Round 2 for Puzzle 697. You will be able to load in your manual saves from 697 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools, or start from scratch! NOTE: If you did not manually save a solution in puzzle 697, you can go back to 697, manually save it, and the solution should appear in your manual saves for this puzzle. PLEASE NOTICE that Valine 32 can be mutated!

700: Revisiting Puzzle 52 (Bacteria Energy)

This is a throwback puzzle to a puzzle that was up the very first week of Foldit. This protein has 103 side chains. It is an energy-coupling protein from bacteria.

699: De-novo Freestyle 22 Round 2

This is Round 2 for Puzzle 693. You will be able to load in your manual saves from 693 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 693, you can go back to 693, manually save it, and the solution should appear in your manual saves for this puzzle.

697: Second Hand-Folding Sepsis Puzzle

Sugar molecules such as the one here are coated on the surface of many human pathogens. We are attempting to increase the protein-sugar binding interactions by allowing you to redesign & insert up to 6 residues to form additional hydrogen bonds with the sugar. To encourage this, only GUI scripts are allowed, and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You will be able to load in your solutions from the first puzzle and refine them with scripting and sharing. Please read the new puzzle comments for more details. AND PLEASE NOTICE that Valine 32 can be mutated!

698: Human cancer protein interaction network target

The solution structure of this dead ringer-like protein has already been solved using NMR, but the crystal structure has yet to be released. We are giving you all 20 models from the NMR ensemble. Every time you reset the puzzle it will cycle through these 20 structures and they are available in the Alignment Tool so you can use partial threading between them. We look forward to seeing how close to the crystal structure you are able to get!

698 (<15): Human cancer protein interaction network target

The solution structure of this dead ringer-like protein has already been solved using NMR, but the crystal structure has yet to be released. We are giving you all 20 models from the NMR ensemble. Every time you reset the puzzle it will cycle through these 20 structures and they are available in the Alignment Tool so you can use partial threading between them. We look forward to seeing how close to the crystal structure you are able to get! For players with fewer than 15 global points.

698 (<150): Human cancer protein interaction network target

The solution structure of this dead ringer-like protein has already been solved using NMR, but the crystal structure has yet to be released. We are giving you all 20 models from the NMR ensemble. Every time you reset the puzzle it will cycle through these 20 structures and they are available in the Alignment Tool so you can use partial threading between them. We look forward to seeing how close to the crystal structure you are able to get! For players with fewer than 150 global points.

695: 70 Residue Trimer [deprecated]

This is a 70 residue symmetric trimer design puzzle; there will be three symmetric chains to manage. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blogpost about this: http://fold.it/portal/node/993871

696: Revisiting Puzzle 481

We are revisiting old Foldit puzzles so we can compare results to

693: Hand-Folding De-novo Freestyle 22

We are giving you another currently unsolved protein as an extended chain, but this time only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.