Foldit Puzzles

676: 76 Residue Monomer Freestyle

We are giving you a single chain of 76 residues to design. Nearing the end of this puzzle, we will post a 76 residue symmetric dimer puzzle where you will be able to load your solution from this monomer into the dimer. Keep that in mind when you are designing your monomer.

678: Large CASP ROLL Target R0027 with symmetry

This one is going to be tough! Again the CASP organizers have told us that this "protein is known to form very stable homo-trimers", so we are again giving you the 5 RosettaServer models for R0027 with symmetry. Resetting the puzzle will cycle through the 5 different server predictions (as well as an extended conformation). More details about this CASP target are in the puzzle comments.

677: CASP ROLL Target R0026 with symmetry

The CASP organizers have told us that this "protein is known to form very stable homo-trimers", so we are giving you the 5 RosettaServer models for R0026 with symmetry. Resetting the puzzle will cycle through the 5 different server predictions (as well as an extended conformation). More details about this CASP target are in the puzzle comments.

679: De-novo Freestyle 20

This puzzle had incorrect secondary structure predictions and was replaced by 679b: http://fold.it/portal/node/994551

674: CASP ROLL Target R0027 - Turkey Adenovirus

The next CASP ROLL target is another tough one. We are again providing you with 3 templates for now, and will give you some server predictions once they are released. Feel free to just work off the starting extended chain if you don't trust the alignments. More details about this CASP target are in the puzzle comments. Due to the size, we're giving you a few extra days to work on this one.

675: Hydrogen-producing Catalyst Dimer (Fixed)

This repost fixes the crashing bug with segment 2 being mutated to GLY. You can load your saved solutions from the previous puzzle to this one.

673: CASP ROLL Target R0026 - Snake Adenovirus

CASP ROLL is back! This latest target is particularly difficult, as we have very low confidence in the templates (you will too once you see them!). We are providing you with 3 templates for now, and will give you some server predictions once they are released. Feel free to just work off the starting extended chain if you don't trust the alignments. More details about this CASP target are in the puzzle comments.

675: Hydrogen-producing Catalyst Dimer (DEPRECATED)

This puzzle has been deprecated. Please reload your solutions in "675: Hydrogen-producing Catalyst Dimer (Fixed)"

670: 30 Residue Symmetric Dimer of Dimers Freestyle Retry

Puzzle 670 is a small (30 residue) symmetric tetramer design puzzle. In other words you will be working with a protein that is made up of 4 symmetric chains. Symmetry becomes complicated when you are working with more than 3 chains. Tetramers, which we learned have 4 chains, can be arranged in a ring (called "C4" symmetry). Or, they can be arranged as a dimer of dimers ("D2" or "two-by-two" symmetry - 2 dimers put together forming a total of 4 symmetric sub-units). The dimer of dimers arrangement is much more common in nature. Keep in mind that symmetric proteins rely on more than just how well-folded each chain is. They also rely on how well the chains interface together. This protein has two fundamentally different interfaces: the interface between chains A and B, and the interface between dimer AB and its partner, CD.

672: Starting Asymmetry

This puzzle starts out asymmetric but needs to be made symmetric. You can move one half of it to make it match the other half, and fit them together!