Foldit Puzzles

691: 60 Residue Tetramer

This is a 60 residue symmetric tetramer design puzzle; there will be four symmetric chains to manage. This particular type of symmetry is a ring (C4) symmetry. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blogpost about this: http://fold.it/portal/node/993871

694: CASP T0711 Disulfide Repost Round 2

This is Round 2 for Puzzle 689. You will be able to load in your manual saves from 689 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 689, you can go back to 689, manually save it, and the solution should appear in your manual saves for this puzzle.

690: 76 Residue Dimer

This is a 76 residue symmetric dimer design puzzle. You will be able to load in your monomer solutions from "687: 76 Residue Monomer Repost".

692b: Refinement of Puzzle 671 Open Phase

This is Round 2 for Puzzle 685. You will be able to load in your manual saves from 685 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools, or start from scratch! NOTE: If you did not manually save a solution in puzzle 685, you can go back to 685, manually save it, and the solution should appear in your manual saves for this puzzle. Manual saves from 692 can also be loaded.

689b: Hand-Folding CASP10 T0711 Repost

We are reposting this 33 residue CASP10 target to try out the new Disulfide Count Score Filter. Only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. We are again giving you the top-predicted templates from 3 different alignment programs. More details about this CASP target are in the puzzle comments.

689: (Old) Hand-Folding CASP10 T0711 Repost

This puzzle has been reposted. Please use the new version of this puzzle, 689b. You may load your MANUAL saves into the new puzzle. We apologize for any inconvenience.

688: (Old) H-Bonding the Hydrogen-producing Catalyst Dimer

This puzzle has been reposted. Please use the new version of this puzzle, 688b. You may load your MANUAL saves into the new puzzle.

688b: H-Bonding the Hydrogen-producing Catalyst Dimer

This is the sequel to puzzle 675, where you folded two symmetric chains attached to a central catalyst molecule. We've kept the catalyst and the chains identical, but we're moving beyond just folding: it's time to make this catalyst go turbo. It needs protons fed to its inner nitrogen (an H-bond acceptor) to go faster, so we're giving you a large bonus for making an H-bond to this atom. Fair warning: it's a bit crowded in there, so the angle has to be just-right to avoid a clash.

686: De-novo Freestyle 21

This currently unsolved short protein does not have any templates that we can use, so we are giving it to you as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

687: 76 Residue Monomer Repost

We are giving you a single chain of 76 residues to design. You will need the latest version of the client to play this puzzle