Foldit Puzzles

816: Unsolved Electron Density: Round 2

This is Round 2 for Unsolved Electron Density Puzzle 813. You will be able to load in your manual saves from 813 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 813, you can go back to 813, manually save it, and the solution should appear in your manual saves for this puzzle.

815: Revisiting Puzzle 87: Zinc Binding Protein

This is a throwback puzzle to the early days of Foldit. A type of metal binding protein. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

814: Ferredoxin Pentamer Design: Round 2 (without fragment filter)

This is a repost of Puzzle 805, with a few important changes. The protein backbone is no longer frozen, but there is an RMSD condition on most of the residues, to maintain the ferredoxin-like fold. This protein chain includes an extra helix at the N- or C-terminus, although you can redesign it to whatever shape you like—this helix is ignored by the RMSD condition. Reset the puzzle to alternate between the extended N- and C-terminus versions. This puzzle also includes a Residue IE filter, which monitors that all PHE, TYR, and TRP residues are scoring well.

814: Ferredoxin Pentamer Design: Round 2

This is a repost of Puzzle 805, with a few important changes. First of all, this puzzle is debuting the new Fragment Filter and Remix Tool to help you design proteins that are likely to fold up in the lab. The protein backbone is no longer frozen, but there is an RMSD condition on most of the residues, to maintain the ferredoxin-like fold. This protein chain includes an extra helix at the N- or C-terminus, although you can redesign it to whatever shape you like—this helix is ignored by the RMSD condition. Reset the puzzle to alternate between the extended N- and C-terminus versions. This puzzle also includes a Residue IE filter, which monitors that all PHE, TYR, and TRP residues are scoring well.

813: Unsolved Electron Density: Hand-folding Round

The Baker Lab and its collaborators have been unable to solve the crystal structure of this protein. The automated methods have been able to generate a model that fits part of the density, but we need your help to get the rest of the structure to fit the remaining density. We're posting this one in 2 rounds, only GUI scripts are allowed and sharing has been disabled for this round. You'll be able to load in your solutions from this puzzle and use scripting and sharing in the next round. Please help us solve the structure of this protein!

812: Revisiting Puzzle 86: Nematode

This is a throwback puzzle to the early days of Foldit. This protein is an anticoagulant, meaning it is used to clot blood. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

811: Abeta Binder Redesign: Round 2

This is a follow-up puzzle to Puzzle 801b. We chose nine of the most promising solutions from that puzzle and added an extra beta-strand to each subunit of the Abeta binder—reset this puzzle to cycle through these nine starting structures. Like in Puzzle 801b, the Abeta protein backbone is frozen, and now you can mutate all residues in the binder subunits. Each chain has a separate RMSD condition, so only slight backbone movements will be tolerated, although you will be able to move the extra beta strand freely. This puzzle also includes a Residue IE filter, which monitors that all PHY, TYR, and TRP residues are scoring well. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions. See the new blog entry about this puzzle for more information and a picture of the sort of backbone configuration that we're aiming for.

810: De-novo Cryo-electron Density: Round 2

This is Round 2 for Puzzle 807. You will be able to load in your manual saves from 807 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 807, you can go back to 807, manually save it, and the solution should appear in your manual saves for this puzzle.

809: Revisiting Puzzle 85: Cell Adhesion Protein

This is a throwback puzzle to the early days of Foldit. This protein is involved in the process of binding cells to each other and other structures. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

808: Abeta Binder Piecewise Design

This is a different type of design puzzle from those you are most familiar with. Instead of designing a single long chain, here you can design a set of short peptides as disjointed sections of a larger protein—we don't want you to worry about designing connections between the short chains in this puzzle. See the new blog post about this for more information. The Abeta protein backbone is frozen in this puzzle, but there are eight short chains that you can completely redesign. This puzzle also includes a Residue IE filter, which monitors that all PHE, TYR, and TRP residues are scoring well. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions. Help us design a tight-binding protein for Abeta!