Foldit Puzzles

801: Abeta Binder Redesign

In this puzzle, you can redesign a protein that was found to bind Abeta, a peptide associated with Alzheimer's disease. See the blog post about this for more information. The Abeta protein backbone is frozen in this puzzle. The binding protein consists of two chains, in which you can mutate all but several loop residues. Each chain has a separate RMSD condition, so only slight backbone movements will be tolerated. This puzzle also includes a Residue IE filter, which monitors that all PHY, TYR, and TRP residues are scoring well. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions. Help us design a tighter-binding protein for Abeta!

802: Revisiting Puzzle 686: Black Belt De-novo

This is a repost of Puzzle 686. When this puzzle ran in March of this year, the structure of this protein was still unknown. Now the structure has been published, and we're making the puzzle available for the Black Belt Folding broadcast this weekend! This puzzle will be used during the Black Belt Folding session, so take some time to familiarize yourself with the puzzle ahead of time. Players will NOT be able to load in any previous solutions for these puzzles.

800: Revisiting Puzzle 82: Cytotoxin

This is a throwback puzzle to the early days of Foldit.This protein is a type of cytotoxin, which is any substance that kills living cells. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

799: Revisiting Puzzle 79: Pheromone

This is a throwback puzzle to the early days of Foldit. This protein is a pheromone from the protozoan Euplotes. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

798: 57 Residue Monomer Design

This is a single-chain design puzzle with 57 residues. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the disulfide filter will give you a bonus for up to two disulfide bonds. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!

797: Revisiting Puzzle 80: Calcium Channel Blocker

This is a throwback puzzle to the early days of Foldit. Calcium channel blockers limit the amount of calcium muscle cells receive, causing them to contract less and decrease blood pressure. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

796: Centroid Quest to the Native 202

This puzzle is a centroid version of Puzzle 202 Quest to the Native 11: Mini-CASP 1, that we posted back in 2009. We're posting it as a centroid Quest to the Native in order to see whether the centroid tools and scoring function are good enough to help you reach the native, and whether there are structures which score better than the native in centroid. More details in the puzzle comments.

Centroid Turkey Egg Lysosyme

This puzzle is a centroid version of one of our old beginner puzzles - The Turkey Egg Lysozyme. We're posting it as a centroid Quest to the Native in order to see whether the centroid tools and scoring function are good enough to help you reach the native, and whether there are structures which score better than the native in centroid. Give it a try!

795: De-novo Freestyle 31: Round 2

This is Round 2 for Puzzle 791. You will be able to load in your manual saves from 791 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 791, you can go back to 791, manually save it, and the solution should appear in your manual saves for this puzzle.

794: De-novo Freestyle 28: Predicted Contacts

This is a follow-up puzzle for Puzzle 771, but this time you have Predicted Contacts to help guide your folding. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). You will notice that different contacts are shown in different shades of blue. Darker blue contacts are stronger predictions and contribute more to the contact multiplier. For this puzzle, you will NOT be able to load in your manual saves from previous rounds.