Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
-
Closed since over 12 years ago807: De-novo Cryo-electron Density: Hand-folding Round
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding807: De-novo Cryo-electron Density: Hand-folding Round
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-FoldingTry to fit this extended chain into the cryo-EM density cloud to gain points. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing.
-
Closed since over 12 years ago
This is a throwback puzzle to the early days of Foldit. A protein from a giant green sea anemone. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
-
Closed since over 12 years ago
In this puzzle you can redesign a protein that was originally designed in the Baker Lab. This ferredoxin-like fold is very stable as a monomer, and the Baker Lab is trying to redesign it to form a symmetric pentamer. The backbone is locked for most of the protein, but you can mutate surface residues to improve the pentamer interface. You can also design a 10 residue extension at the N- or C-terminus to improve the binding interface between monomer units; reset the puzzle to alternate between the extended N- and C-terminus versions. This puzzle also includes a Residue IE filter, which monitors that all PHE, TYR, and TRP residues are scoring well.
-
Closed since over 12 years ago
This is a repost of Puzzle 715. When this puzzle ran in May of this year, the structure of this protein was still unknown. Now the structure has been published, and we're making the puzzle available for the Black Belt Folding broadcast! This puzzle will remain up for longer than usual so that players can practice their newly acquired de-novo skills. Players will NOT be able to load in any previous solutions for these puzzles.
-
Closed since over 12 years ago
This is a throwback puzzle to the early days of Foldit. This toxin is found in cobra venom from Taiwan. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
-
Closed since over 12 years ago
In this puzzle, you can redesign a protein that was found to bind Abeta, a peptide associated with Alzheimer's disease. See the blog post about this for more information. The Abeta protein backbone is frozen in this puzzle. The binding protein consists of two chains, in which you can mutate all but several loop residues. Each chain has a separate RMSD condition, so only slight backbone movements will be tolerated. This puzzle also includes a Residue IE filter, which monitors that all PHY, TYR, and TRP residues are scoring well. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions. Help us design a tighter-binding protein for Abeta!
-
Closed since over 12 years ago
In this puzzle, you can redesign a protein that was found to bind Abeta, a peptide associated with Alzheimer's disease. See the blog post about this for more information. The Abeta protein backbone is frozen in this puzzle. The binding protein consists of two chains, in which you can mutate all but several loop residues. Each chain has a separate RMSD condition, so only slight backbone movements will be tolerated. This puzzle also includes a Residue IE filter, which monitors that all PHY, TYR, and TRP residues are scoring well. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions. Help us design a tighter-binding protein for Abeta!
-
Closed since over 12 years ago
This is a repost of Puzzle 686. When this puzzle ran in March of this year, the structure of this protein was still unknown. Now the structure has been published, and we're making the puzzle available for the Black Belt Folding broadcast this weekend! This puzzle will be used during the Black Belt Folding session, so take some time to familiarize yourself with the puzzle ahead of time. Players will NOT be able to load in any previous solutions for these puzzles.
-
Closed since over 12 years ago
This is a throwback puzzle to the early days of Foldit.This protein is a type of cytotoxin, which is any substance that kills living cells. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
-
Closed since over 12 years ago
This is a throwback puzzle to the early days of Foldit. This protein is a pheromone from the protozoan Euplotes. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.