Foldit Puzzles

792: Revisiting Puzzle 79: Pheromone

This is a throwback puzzle to the early days of Foldit. This protein is a pheromone from the protozoan Euplotes. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

793: Revisiting Puzzle 81: Calcium Ion Binding Protein

This is a throwback puzzle to the early days of Foldit. This protein is involved in the act of muscle contraction. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

791: De-novo Freestyle 31: Hand-folding Round

We are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

789: 85 Residue Monomer Design

This is a straightforward design puzzle with only a single chain. There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.

788: Revisiting Puzzle 78: Membrane Protein

This is a throwback puzzle to the early days of Foldit. This protein resides on a cell membrane. This puzzle has 80 sidechains. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

787: Unsolved Salmonella Bacteriophage: Trimmed Cryo-electron Density

We are giving you a player model from Puzzle 772 that was created by grogar7, Galaxie, & Susume. This time we have more aggressively trimmed the density map. You will NOT be able to load in your solutions from the previous puzzles for this one, as we want you to focus on this particular topology. You can find more details in the puzzle comments.

790: Quick Revisiting of Puzzle 76: Plant Seed Protein

This is a quick puzzle following up on the same revisited puzzle which just closed. The only aspect which is different in this quick puzzle is that the disulfide count filter is present, so you will have the chance to form disulfide bonds and get bonus points. This quick puzzle will only be up for a few days.

786: De-novo Freestyle 30: Round 2

This is Round 2 for Puzzle 782. You will be able to load in your manual saves from 782 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 782, you can go back to 782, manually save it, and the solution should appear in your manual saves for this puzzle.

785: Revisiting Puzzle 77: Gene Regulation Protein

This is a throwback puzzle to the early days of Foldit. This protein is an example of a chaperone protein, one which assists in the folding of other proteins. This puzzle has 68 side chains. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

784: De-Novo Freestyle 31 with Predicted Contacts

This is the first puzzle to include a new kind of data: Predicted Contacts. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). Blue squares represent predicted contacts; a darker blue color means there is stronger evidence for a contact prediction. There is a score multiplier that increases whenever you bring together two residues that make a predicted contact. Find a high-scoring fold that satisfies the most contact predictions!