Foldit Puzzles

783: 60 Residue Symmetric Dimer with a Disulfide

This is a 60 residue symmetric dimer design puzzle; there will be two symmetric chains to manage. This puzzle also contains a disulfide filter: you will receive a bonus for making one disulfide bond between the two subunits, but there is no bonus for a disulfide bond between two residues of the same subunit. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blog post about this for more information. In addition to the disulfide filter, there are two other filters enabled on this puzzle: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.

782: De-novo Freestyle 30: Hand-folding Round

We are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing.

781: Revisiting Puzzle 76: Plant Seed Protein

This is a throwback puzzle to the early days of Foldit. This protein is found in plant seeds. It has 46 sidechains. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

779: Unsolved Salmonella Bacteriophage: Trimmed Cryo-electron Density

This is a repost of Puzzle 772, but this time we have more aggressively trimmed the density map. You can load in your solutions from the previous puzzles (737, 740, 749, 756, 765, and 772) and can find more details in the puzzle comments.

780: De-novo Freestyle 29 with Alignments

This is a repost of Puzzle 776, with alignments to some distant homologues. You will be able to load in your manual saves from puzzles 773 and 776 to use as a starting point here. NOTE: If you did not manually save a solution in puzzle 773 or 776, you can go back, manually save it, and the solution should appear in your manual saves for this puzzle.

778: 58 Residue D2 Tetramer Design

This is a 58 residue tetramer design puzzle with D2 symmetry; there will be four symmetric chains to manage. Note that the score of a symmetric protein relies not only on how well-folded each chain is, but also on how well the chains interface together. See the blog post about this for more information. There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well, and the Core Exists filter checks that at least 30% of the residues are buried in the core of your design. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.

777: Revisiting Puzzle 75: Antifreeze Protein

This is a throwback puzzle to the early days of Foldit. This is an antifreeze protein. It has 66 sidechains. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

776: De-novo Freestyle 29: Round 2

This is Round 2 for Puzzle 773. You will be able to load in your manual saves from 773 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 773, you can go back to 773, manually save it, and the solution should appear in your manual saves for this puzzle.

775: Player-Solution Redesign: Negative Design

In this puzzle you can redesign a player solution from Puzzle 742. The starting structure is the monomer subunit for a top-scoring solution by Galaxie, jamiexq, and tokens. See if you can find a higher-scoring sequence that stabilizes the design fold! This puzzle has an RMSD condition, so don't stray too far from the starting fold. We've also included alignments to two decoy folds—alternative high-scoring folds for the same amino acid sequence. New designs that also destabilize the decoy folds will be prime candidates for synthesis in the Baker lab! See the puzzle comments for more details.

774: Revisiting Puzzle 74: Platypus Venom

This is a throwback puzzle to the early days of Foldit. This is a protein found in duckbilled platypus venom. It has 42 sidechains. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.