Foldit Puzzles

788: Revisiting Puzzle 78: Membrane Protein

This is a throwback puzzle to the early days of Foldit. This protein resides on a cell membrane. This puzzle has 80 sidechains. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

787: Unsolved Salmonella Bacteriophage: Trimmed Cryo-electron Density

We are giving you a player model from Puzzle 772 that was created by grogar7, Galaxie, & Susume. This time we have more aggressively trimmed the density map. You will NOT be able to load in your solutions from the previous puzzles for this one, as we want you to focus on this particular topology. You can find more details in the puzzle comments.

790: Quick Revisiting of Puzzle 76: Plant Seed Protein

This is a quick puzzle following up on the same revisited puzzle which just closed. The only aspect which is different in this quick puzzle is that the disulfide count filter is present, so you will have the chance to form disulfide bonds and get bonus points. This quick puzzle will only be up for a few days.

786: De-novo Freestyle 30: Round 2

This is Round 2 for Puzzle 782. You will be able to load in your manual saves from 782 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 782, you can go back to 782, manually save it, and the solution should appear in your manual saves for this puzzle.

785: Revisiting Puzzle 77: Gene Regulation Protein

This is a throwback puzzle to the early days of Foldit. This protein is an example of a chaperone protein, one which assists in the folding of other proteins. This puzzle has 68 side chains. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

784: De-Novo Freestyle 31 with Predicted Contacts

This is the first puzzle to include a new kind of data: Predicted Contacts. You can see the predicted contacts for this protein by clicking the Contact Map button in the Main menu (Selection Interface) or in the Actions tab (Classic Interface). Blue squares represent predicted contacts; a darker blue color means there is stronger evidence for a contact prediction. There is a score multiplier that increases whenever you bring together two residues that make a predicted contact. Find a high-scoring fold that satisfies the most contact predictions!

783: 60 Residue Symmetric Dimer with a Disulfide

This is a 60 residue symmetric dimer design puzzle; there will be two symmetric chains to manage. This puzzle also contains a disulfide filter: you will receive a bonus for making one disulfide bond between the two subunits, but there is no bonus for a disulfide bond between two residues of the same subunit. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blog post about this for more information. In addition to the disulfide filter, there are two other filters enabled on this puzzle: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.

782: De-novo Freestyle 30: Hand-folding Round

We are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing.

781: Revisiting Puzzle 76: Plant Seed Protein

This is a throwback puzzle to the early days of Foldit. This protein is found in plant seeds. It has 46 sidechains. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

779: Unsolved Salmonella Bacteriophage: Trimmed Cryo-electron Density

This is a repost of Puzzle 772, but this time we have more aggressively trimmed the density map. You can load in your solutions from the previous puzzles (737, 740, 749, 756, 765, and 772) and can find more details in the puzzle comments.