Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed since almost 13 years ago759: Large CASP ROLL R0040
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL759: Large CASP ROLL R0040
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLThe last CASP ROLL target was cancelled, but we have one to replace it! This is a large CASP ROLL target with 205 residues. There are no homologs, so we are starting you from an extended chain. After this puzzle closes, there will be one more round with server predictions.
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Closed since almost 13 years ago
756: Unsolved Salmonella Bacteriophage: Cryo-electron microscopy
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density756: Unsolved Salmonella Bacteriophage: Cryo-electron microscopy
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron DensityThe Unsolved Salmonella Bacteriophage protein that you have been working on (in puzzles 737, 740, 749) has Cryo-electron microscopy (cryo-EM) data that we can use. We are giving you the same puzzle, but this time with Cryo-EM data as an Electron Density puzzle! This is the best available experimental data that exists for this protein, so we hope it is useful to you. You can load in your previous solutions from the previous puzzles (737, 740, 749) and can find more details in the puzzle comments.
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Closed since almost 13 years ago
758: Revisiting Puzzle 69: Scorpion Toxin
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction758: Revisiting Puzzle 69: Scorpion Toxin
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionThis is a throwback puzzle to the early days of Foldit. This is a toxin used by scorpions. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
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Closed since almost 13 years ago
757: De-novo Freestyle 27: Hand-folding Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding757: De-novo Freestyle 27: Hand-folding Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-FoldingWe are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
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Closed since almost 13 years ago
755: Server Models for R0039
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL755: Server Models for R0039
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLAs mentioned in Puzzle 752, we are giving you server predictions for this CASP ROLL target. Resetting the puzzle will cycle through 5 different server predictions and they are available in the Alignment Tool so you can use partial threading between them. Please try out each start, as the topology that initially scores poorly may actually be the closest to the native and will eventually score better than everything else.
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Closed since almost 13 years ago
754: Revisiting Puzzle 68: Bos taurus
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction754: Revisiting Puzzle 68: Bos taurus
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionThis is a throwback puzzle to the early days of Foldit. A protein from domestic cattle. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
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Closed since almost 13 years ago
753: 91 Residue Dimer Design
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry753: 91 Residue Dimer Design
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetryThis is a 91 residue symmetric dimer design puzzle; there will be two symmetric chains to manage. Note that the score of a symmetric protein relies not only on how well-folded each chain is, but also on how well the chains interface together. See the blog post about this for more information. There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.
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Closed since almost 13 years ago
751: Revisiting Puzzle 67: Integrase
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction751: Revisiting Puzzle 67: Integrase
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionThis is a throwback puzzle to the early days of Foldit. This protein is used by many viruses to insert their DNA into the human genome. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
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Closed since almost 13 years ago
752: CASP ROLL R0039: Round 2 with Templates
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL752: CASP ROLL R0039: Round 2 with Templates
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLThis is Round 2 for Puzzle 748. You will be able to load in your manual saves from 748 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. We're also providing you with two templates in the alignment tool, and there will be one more round with server predictions. NOTE: If you did not manually save a solution in puzzle 748, you can go back to 748, manually save it, and the solution should appear in your manual saves for this puzzle.
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Closed since almost 13 years ago
750: R0034 with Electron Density: Round 2
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL750: R0034 with Electron Density: Round 2
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLWe have trimmed the huge density cloud from Puzzle 746 by using your top-scoring solutions from Round 1. This will hopefully make this round a lot easier for everyone! You will be able to load in your manual saves from the previous round. NOTE: If you did not manually save a solution in puzzle 746, you can go back to 746, manually save it, and the solution should appear in your manual saves for this puzzle.