Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
-
Closed since almost 13 years ago749: Unsolved Salmonella Bacteriophage: Server Starts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction749: Unsolved Salmonella Bacteriophage: Server Starts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionWe are now giving you 10 server predictions for this unsolved protein from Puzzles 737 & 740. Resetting the puzzle will cycle through 10 different Quark Server predictions and they are available in the Alignment Tool so you can use partial threading between them. We are giving you a few extra days to work on this puzzle since there are 10 different models, so please try out each start as the topology that initially scores poorly may actually be the closest to the correct unknown structure. More details in the puzzle comments.
-
Closed since almost 13 years ago
748: CASP ROLL R0039: Hand-folding Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding748: CASP ROLL R0039: Hand-folding Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-Folding CASP ROLL Hand-FoldingWe are giving you another currently unsolved protein with no homologs as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
-
Closed since almost 13 years ago
747: Revisiting Puzzle 66: Cytochrome
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction747: Revisiting Puzzle 66: Cytochrome
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionThis is a throwback puzzle to the early days of Foldit. Cytochromes are used for oxidizing and reducing. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
-
Closed since almost 13 years ago
746: R0034 with Electron Density: Round 1
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL746: R0034 with Electron Density: Round 1
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLThis Electron Density puzzle is going to be as hard as it gets, which is why we are splitting it into 2 rounds. For this round, we have not trimmed the density. Again, the automated methods were unable to solve this structure using this huge density cloud. We will trim this density in Round 2 based on your top-scoring solutions for this round! Unfortunately there are no available templates to start with for this puzzle, so you'll have to use all your Electron Density folding skills to fit the density as well as you can! The secondary structure predictions have been loaded onto the starting model, with more details posted in the puzzle comments.
-
Closed since almost 13 years ago
745: Quick Thioredoxin Repost
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction745: Quick Thioredoxin Repost
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionThis is a repost of Puzzle 739 (while it's still fresh in your minds) but this time around we've added the Disulfide Count Score Filter. You will NOT be able to load in your solutions from Puzzle 739. More details in the puzzle comments.
-
Closed since almost 13 years ago
744: Revisiting Puzzle 65: Short Puzzle
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction744: Revisiting Puzzle 65: Short Puzzle
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionThis is a throwback puzzle to the early days of Foldit. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.
-
Closed since almost 13 years ago
743: De-novo Freestyle 26: Round 2
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction743: De-novo Freestyle 26: Round 2
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionThis is Round 2 for Puzzle 738. You will be able to load in your manual saves from 738 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 738, you can go back to 738, manually save it, and the solution should appear in your manual saves for this puzzle.
-
Closed since almost 13 years ago
742: 65 Residue Trimer Design
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry742: 65 Residue Trimer Design
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetryThis is a 65 residue symmetric trimer design puzzle; there will be three symmetric chains to manage. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blog post about this for more information. There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.
-
Closed since almost 13 years ago
740: Unsolved Salmonella Bacteriophage: Freestyle Round 2
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction740: Unsolved Salmonella Bacteriophage: Freestyle Round 2
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionThis is Round 2 for this unsolved protein from Puzzle 737. You will be able to load in your manual saves from 737 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 737, you can go back to 737, manually save it, and the solution should appear in your manual saves for this puzzle.
-
Closed since almost 13 years ago
739: Revisiting Puzzle 64: Thioredoxin
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction739: Revisiting Puzzle 64: Thioredoxin
Closed Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Beginner Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction PredictionThis is a throwback puzzle to the early days of Foldit. This enzyme is used to process iron. I bet ironman has lots of these proteins. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.