Foldit Puzzles

743: De-novo Freestyle 26: Round 2

This is Round 2 for Puzzle 738. You will be able to load in your manual saves from 738 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 738, you can go back to 738, manually save it, and the solution should appear in your manual saves for this puzzle.

742: 65 Residue Trimer Design

This is a 65 residue symmetric trimer design puzzle; there will be three symmetric chains to manage. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blog post about this for more information. There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.

740: Unsolved Salmonella Bacteriophage: Freestyle Round 2

This is Round 2 for this unsolved protein from Puzzle 737. You will be able to load in your manual saves from 737 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 737, you can go back to 737, manually save it, and the solution should appear in your manual saves for this puzzle.

739: Revisiting Puzzle 64: Thioredoxin

This is a throwback puzzle to the early days of Foldit. This enzyme is used to process iron. I bet ironman has lots of these proteins. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

741b: Blind Electron Density 9; Now with Templates!

This Electron Density puzzle is a bit different because we have not trimmed the density. Again, the automated methods were unable to solve this structure using this huge density cloud. To make it easier for you, we are providing two different templates to start with. Use all your Electron Density & Alignment Tool folding skills to fit the density as well as you can and beat the automated methods! The secondary structure predictions have been loaded onto the starting model, with more details posted in the puzzle comments. NOTE: You will need to latest client to play this puzzle!

741 (OLD): Blind Electron Density 9; Now with Templates!

The extended chain on this puzzle did not have the correct secondary structure predictions. We are leaving this puzzle open for a few days (for your scripts) but this version of the puzzle is worth 0 points. You will be able to load in your manual saves from this puzzle in 741b. We apologize for this!

738: De-novo Freestyle 26: Hand-folding Round

This is a funny little protein that was designed by scientists in the Baker lab. It has only been crystallized as a dimer, but it is known to exist in solution as a monomer. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

737: Unsolved Salmonella Bacteriophage: Freestyle Hand-folding Round

This is the first of many puzzles for this unsolved protein. We are giving you an extended chain; sadly this protein has no homologs or templates we can use. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, it will be re-posted and LUA scripts and sharing will be allowed. You'll also be able to load in your solutions from this puzzle. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

736: Revisiting Puzzle 63: Spinach Protein

Eat your spinach! This protein is good for you. This is a throwback puzzle to the early days of Foldit. We are revisiting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

735: Player-Solution Loop Redesign: Round 2

This is a puzzle where you can redesign part of a player-designed protein. Galaxie's top-scoring solution from Puzzle 720 shows promise in the Baker Lab's folding simulations, but one loop seems to be a little troublesome. In Puzzle 734, you were allowed to design just this short loop, but now you can redesign an entire helix. Like the last puzzle, you can insert up to four residues and mutate residues near the helix, but the rest of the protein is frozen. The scientists at the Baker Lab like the general placement of this helix, so there is also an RMSD condition for the helix residues. You can load in solutions from Puzzle 734.