Foldit Puzzles

716: Two chains of Insulin Mutant

We recently posted one of the chains of a mutant of the Insulin protein (Puzzle 707), but this time we are giving you both chains to work with. You'll need to fold both of them up and pack them together.

713: 5-year-anniversary puzzle: 2011

Puzzle "H2N2 Flu Design" is from our 4th year of Foldit. The goal is to design the interface of these designs so that it can bind to the H2 subtype of Influenza. If you are new to Foldit, make sure you have completed the Intro Puzzle 5-2 and the Protein Design Intro Puzzles.

712: 5-year-anniversary puzzle: 2010

Puzzle "Unsolved monkey virus protein" is from the third year of Foldit, as we look back at the last 5 years. Of course we had to pick this puzzle when looking back at 2010! We are giving you these 10 incorrect NMR models to work on. Every time you reset the puzzle it will cycle through these 10 structures and they are available in the Alignment Tool so you can use partial threading between them. You can read all about why this Foldit puzzle was so important in the puzzle comments.

715: De-novo Freestyle 24: Round 2

This is Round 2 for Puzzle 709. You will be able to load in your manual saves from 709 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 709, you can go back to 709, manually save it, and the solution should appear in your manual saves for this puzzle.

711: 5-year-anniversary puzzle: 2009

Puzzle "Loop Out of Place" is from the second year of Foldit, as we look back at the last 5 years. There is a particular loop that needs to be fixed in this puzzle.

710: 5-year-anniversary puzzle: 2008

Puzzle "Designer Protein Top7" is from the first year of Foldit, as we look back at the last 5 years. This protein has 92 residues and was the Baker Lab's first successfully designed protein.

709: De-novo Freestyle 24: Hand-folding Round

We are giving you another currently unsolved protein (this one doesn't have any homologs) as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

708: Multi-Start 76 Residue Symmetric Dimer

We are giving you a 76 residue symmetric dimer to design. This is a multi-start puzzle, with three starting points that you will cycle through when you reset the puzzle. There are two filters enabled on this puzzle. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The "Core Exists" filter ensures the number of residues in the core is at least 30%.

705: Centroid QTTN: Hand-folding Round

This is the first 'centroid mode' puzzle ever, a 398 residue Salmonella typhimurium protein.

707: Revisiting Puzzle 58 (Insulin Mutant)

This is a mutant of the Insulin protein with 21 sidechains.