Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed since almost 13 years ago721: Solo Hand-Folding Sepsis Puzzle 3
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding721: Solo Hand-Folding Sepsis Puzzle 3
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-FoldingWe are giving you Museka's solution from Puzzle 684 as a starting model to work on, we have deleted 1 residue (you may delete even more). The sugar molecule bound to this protein is part of a larger carbohydrate structure that is a component of the bacterial cell surface; it is not an isolated sugar as implied by the crystal structure. Therefore, it is crucial that the top portion of the sugar be free of obstructions from the protein; so your designs should only access the sugar from the bottom and sides. More details in the puzzle comments. Because this is a Hand-Folding round, only GUI scripts are allowed and sharing has been disabled.
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Closed since almost 13 years ago
We are reposting puzzle 716, but this time with the new Disulfide Count Score Filter that gives you a bonus for forming bridges. More info about Disulfide Bridges in Foldit here: http://foldit.wikia.com/wiki/Disulfide_Bridge. Once formed, you'll need to click "Show Bonds (sidechain)" to view them.
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Closed since almost 13 years ago
720: Quick Puzzle: 76 Residue Dimer
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry720: Quick Puzzle: 76 Residue Dimer
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetryThis is 76 residue symmetric dimer design puzzle, much like Puzzle 708. There are two flters enabled on this puzzle. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The "Core Exists" filter ensures the number of residues in the core is at least 30%. We're starting you with johnmitch's monomer solution to Puzzle 687, but we've mutated all residues to isoleucine. You'll have to make your own mutations and design a well-packed dimer interface to increase your score. This is just a starting point, of course; you are free to redesign the entire protein in this puzzle.
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Closed since almost 13 years ago
718: Hand-Folding Flu Puzzle: Design the Core
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding718: Hand-Folding Flu Puzzle: Design the Core
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-FoldingIn this puzzle we are trying to create a new better core for one of the Baker Lab flu proteins. We know what the key interface residues should be, that's why you can't change them, but a new core may increase the stability of the protein. Ultimately a more stable protein might translate into a better protein therapeutic. We don't want you to drift too far from the initial topology, so this puzzle has an RMSD condition. You might want to mutate the core of the protein before you wiggle to not violate this condition. Because this is a Hand-Folding round, only GUI scripts are allowed and sharing has been disabled. More details about all this in the puzzle comments.
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Closed since almost 13 years ago
717: CASP ROLL Target R0034
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL717: CASP ROLL Target R0034
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLCASP ROLL started up again, but this is the first target that isn't too large for Foldit. We are giving you the 5 Rosetta Server models to work on. Resetting the puzzle will cycle through them, please try out all 5 starting points. The secondary structure predictions are provided on the extended chain in the Alignment Tool, with more details posted in the puzzle comments.
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Closed since almost 13 years ago
714: 5-year-anniversary puzzle: 2012
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density714: 5-year-anniversary puzzle: 2012
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Electron Density Electron Density Electron Density Electron Density Electron Density Electron Density Electron DensityPuzzle "Blind Electron Density 2" is from our 5th year of Foldit. This was our second electron density puzzle with real data. Try to fit the protein into the density to get the best score!
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Closed since almost 13 years ago
We recently posted one of the chains of a mutant of the Insulin protein (Puzzle 707), but this time we are giving you both chains to work with. You'll need to fold both of them up and pack them together.
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Closed since almost 13 years ago
Puzzle "H2N2 Flu Design" is from our 4th year of Foldit. The goal is to design the interface of these designs so that it can bind to the H2 subtype of Influenza. If you are new to Foldit, make sure you have completed the Intro Puzzle 5-2 and the Protein Design Intro Puzzles.
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Closed since almost 13 years ago
Puzzle "Unsolved monkey virus protein" is from the third year of Foldit, as we look back at the last 5 years. Of course we had to pick this puzzle when looking back at 2010! We are giving you these 10 incorrect NMR models to work on. Every time you reset the puzzle it will cycle through these 10 structures and they are available in the Alignment Tool so you can use partial threading between them. You can read all about why this Foldit puzzle was so important in the puzzle comments.
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Closed since almost 13 years ago
This is Round 2 for Puzzle 709. You will be able to load in your manual saves from 709 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 709, you can go back to 709, manually save it, and the solution should appear in your manual saves for this puzzle.