Foldit Puzzles

732: Quick De-novo Freestyle 25: Round 2

This is Round 2 for Puzzle 728. You will be able to load in your manual saves from 728 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 728, you can go back to 728, manually save it, and the solution should appear in your manual saves for this puzzle.

729: Revisiting Puzzle 59: TCR Binding Protein

Here is another puzzle from the early days of Foldit. This is a protein that binds to the cytoplasmic domain of the T-cell Receptor. We are revisiting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

730: Blind Electron Density Puzzle 8

This is another very difficult Electron Density puzzle where the automated methods were unable to solve this structure using this density. Here is another chance for you to outsmart the computers! Use all your Electron Density folding skills to fit the density as well as you can. Again, secondary structure predictions have been loaded onto the starting model, with more details posted in the puzzle comments.

728: De-novo Freestyle 25: Hand-folding Round

We are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

727: Third Sepsis Puzzle: Round 2

This is Round 2 for Puzzle 721. You will be able to load in your manual saves from 721 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools, or start from scratch!

726: Revisiting Puzzle 62 (Halorhodopsin)

This is a throwback puzzle to the early days of Foldit. This protein is championed as the holy grail of neuroengineering. It functions to absorb light of a certain wavelength, and in response, it opens up a chloride channel. We are revisiting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

724: Blind Electron Density Puzzle 7

This Electron Density puzzle is going to be as difficult as they get! Why? Because the automated methods for fitting electron density were unable to solve this structure using this density. But where computers fail, Foldit players triumph! Use all your Electron Density folding skills to fit the density as well as you can. As requested in the last Scientist Chat, we have added secondary structure predictions onto the starting model, with more details posted in the puzzle comments.

725: Quick 60 Residue Tetramer Redesign

This is a 60 residue symmetric tetramer design puzzle. The starting structure is a solution to Puzzle 691 that was shared with us by MurloW. The scientists at the Baker Lab like the topology of this solution, but simulations predict that this amino acid sequence will not fold up properly from an extended chain. Help us redesign this solution into a folding protein! The ResidueIE and "Core Exists" filters will make sure PHY, TYR, and TRP residues are scoring well, and that the protein core includes at least 35% of the residues. We look forward to seeing your mutations to this fold, although you are free to redesign the entire protein in this puzzle.

723: Server models for R0034

We are giving you non-Rosetta server predictions for this CASP ROLL target. Resetting the puzzle will cycle through 5 different Zhang Server predictions and they are available in the Alignment Tool so you can use partial threading between them. Please try out each start, as the topology that initially scores poorly may actually be the closest to the native and will eventually score better than everything else. The secondary structure predictions are provided on the extended chain in the Alignment Tool... for real, this time!

722: Design the Core Round 2

This is Round 2 for Puzzle 718. You will be able to load in your manual saves from 718 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 718, you can go back to 718, manually save it, and the solution should appear in your manual saves for this puzzle.