Foldit Puzzles

731b: Unsolved Chicken Anemia Virus Protein

Apoptin is a viral protein of special interest because it targets cancer cells and causes apoptosis. Solving this protein structure would greatly advance research into apoptin’s functionality and development as a method to treat cancer. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. So that you have plenty of time to try out each model, this puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.

731: Unsolved Chicken Anemia Virus Protein (CLOSED and reposted as 731b)

Apoptin is a viral protein of special interest because it targets cancer cells and causes apoptosis. Solving this protein structure would greatly advance research into apoptin’s functionality and development as a method to treat cancer. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. So that you have plenty of time to try out each model, this puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.

733b: Revisiting Puzzle 60: Beta Barrel

Here is another puzzle from the early days of Foldit. This protein has 132 residues and is used for cellular import and export. We are revisiting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. You can load in your manual saves from Puzzle 733, see the puzzle comments for more details.

734: Player-Solution Loop Redesign

This is a puzzle where you can redesign part of a player-designed protein. Galaxie's top-scoring solution from Puzzle 720 shows promise in the Baker Lab's folding simulations, but one loop seems to be a little troublesome. Help us redesign this loop to find a solution that will fold up properly! You can insert up to four residues and mutate residues near the loop, but most of the protein is frozen in this puzzle.

732: Quick De-novo Freestyle 25: Round 2

This is Round 2 for Puzzle 728. You will be able to load in your manual saves from 728 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 728, you can go back to 728, manually save it, and the solution should appear in your manual saves for this puzzle.

729: Revisiting Puzzle 59: TCR Binding Protein

Here is another puzzle from the early days of Foldit. This is a protein that binds to the cytoplasmic domain of the T-cell Receptor. We are revisiting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

730: Blind Electron Density Puzzle 8

This is another very difficult Electron Density puzzle where the automated methods were unable to solve this structure using this density. Here is another chance for you to outsmart the computers! Use all your Electron Density folding skills to fit the density as well as you can. Again, secondary structure predictions have been loaded onto the starting model, with more details posted in the puzzle comments.

728: De-novo Freestyle 25: Hand-folding Round

We are giving you another currently unsolved protein as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

727: Third Sepsis Puzzle: Round 2

This is Round 2 for Puzzle 721. You will be able to load in your manual saves from 721 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools, or start from scratch!

726: Revisiting Puzzle 62 (Halorhodopsin)

This is a throwback puzzle to the early days of Foldit. This protein is championed as the holy grail of neuroengineering. It functions to absorb light of a certain wavelength, and in response, it opens up a chloride channel. We are revisiting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.