Foldit Puzzles

741b: Blind Electron Density 9; Now with Templates!

This Electron Density puzzle is a bit different because we have not trimmed the density. Again, the automated methods were unable to solve this structure using this huge density cloud. To make it easier for you, we are providing two different templates to start with. Use all your Electron Density & Alignment Tool folding skills to fit the density as well as you can and beat the automated methods! The secondary structure predictions have been loaded onto the starting model, with more details posted in the puzzle comments. NOTE: You will need to latest client to play this puzzle!

741 (OLD): Blind Electron Density 9; Now with Templates!

The extended chain on this puzzle did not have the correct secondary structure predictions. We are leaving this puzzle open for a few days (for your scripts) but this version of the puzzle is worth 0 points. You will be able to load in your manual saves from this puzzle in 741b. We apologize for this!

738: De-novo Freestyle 26: Hand-folding Round

This is a funny little protein that was designed by scientists in the Baker lab. It has only been crystallized as a dimer, but it is known to exist in solution as a monomer. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

737: Unsolved Salmonella Bacteriophage: Freestyle Hand-folding Round

This is the first of many puzzles for this unsolved protein. We are giving you an extended chain; sadly this protein has no homologs or templates we can use. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, it will be re-posted and LUA scripts and sharing will be allowed. You'll also be able to load in your solutions from this puzzle. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

736: Revisiting Puzzle 63: Spinach Protein

Eat your spinach! This protein is good for you. This is a throwback puzzle to the early days of Foldit. We are revisiting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

735: Player-Solution Loop Redesign: Round 2

This is a puzzle where you can redesign part of a player-designed protein. Galaxie's top-scoring solution from Puzzle 720 shows promise in the Baker Lab's folding simulations, but one loop seems to be a little troublesome. In Puzzle 734, you were allowed to design just this short loop, but now you can redesign an entire helix. Like the last puzzle, you can insert up to four residues and mutate residues near the helix, but the rest of the protein is frozen. The scientists at the Baker Lab like the general placement of this helix, so there is also an RMSD condition for the helix residues. You can load in solutions from Puzzle 734.

731b: Unsolved Chicken Anemia Virus Protein

Apoptin is a viral protein of special interest because it targets cancer cells and causes apoptosis. Solving this protein structure would greatly advance research into apoptin’s functionality and development as a method to treat cancer. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. So that you have plenty of time to try out each model, this puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.

731: Unsolved Chicken Anemia Virus Protein (CLOSED and reposted as 731b)

Apoptin is a viral protein of special interest because it targets cancer cells and causes apoptosis. Solving this protein structure would greatly advance research into apoptin’s functionality and development as a method to treat cancer. Resetting the puzzle will cycle through 5 Zhang server predictions that are also in the Alignment Tool so you can use partial threading. So that you have plenty of time to try out each model, this puzzle will be up for 10 days and worth 150 global points! More info in the puzzle comments.

733b: Revisiting Puzzle 60: Beta Barrel

Here is another puzzle from the early days of Foldit. This protein has 132 residues and is used for cellular import and export. We are revisiting old Foldit puzzles so we can compare results to see how useful the recent additions to the game have been. You can load in your manual saves from Puzzle 733, see the puzzle comments for more details.

734: Player-Solution Loop Redesign

This is a puzzle where you can redesign part of a player-designed protein. Galaxie's top-scoring solution from Puzzle 720 shows promise in the Baker Lab's folding simulations, but one loop seems to be a little troublesome. Help us redesign this loop to find a solution that will fold up properly! You can insert up to four residues and mutate residues near the loop, but most of the protein is frozen in this puzzle.