Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed since about 13 years agoPuzzle "Loop Out of Place" is from the second year of Foldit, as we look back at the last 5 years. There is a particular loop that needs to be fixed in this puzzle.
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Closed since about 13 years ago
Puzzle "Designer Protein Top7" is from the first year of Foldit, as we look back at the last 5 years. This protein has 92 residues and was the Baker Lab's first successfully designed protein.
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Closed since about 13 years ago
709: De-novo Freestyle 24: Hand-folding Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding709: De-novo Freestyle 24: Hand-folding Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-FoldingWe are giving you another currently unsolved protein (this one doesn't have any homologs) as an extended chain. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
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Closed since about 13 years ago
We are giving you a 76 residue symmetric dimer to design. This is a multi-start puzzle, with three starting points that you will cycle through when you reset the puzzle. There are two filters enabled on this puzzle. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The "Core Exists" filter ensures the number of residues in the core is at least 30%.
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Closed since about 13 years ago
705: Centroid QTTN: Hand-folding Round
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding705: Centroid QTTN: Hand-folding Round
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-FoldingThis is the first 'centroid mode' puzzle ever, a 398 residue Salmonella typhimurium protein.
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Closed since about 13 years ago
This is a mutant of the Insulin protein with 21 sidechains.
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Closed since about 13 years ago
This is Round 2 for Puzzle 703. You will be able to load in your manual saves from 703 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! Unlike Puzzle 703, the secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
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Closed since about 13 years ago
This is a throwback puzzle to the infancy of Foldit. This protein helps control cell growth.
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Closed since about 13 years ago
Resetting this CASP ROLL puzzle will cycle through 10 different server predictions. They are also available in the Alignment Tool so you can use partial threading. The secondary structure prediction are posted in the old puzzle comments.
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Closed since about 13 years ago
703: De-novo Freestyle 23: Hand-folding Round
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding703: De-novo Freestyle 23: Hand-folding Round
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-Folding Hand-FoldingWe are giving you another currently unsolved protein as an extended chain, but this round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. There are no secondary structure predictions for this puzzle!