Foldit Puzzles

706: De-novo Freestyle 23 Round 2

This is Round 2 for Puzzle 703. You will be able to load in your manual saves from 703 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! Unlike Puzzle 703, the secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

704: Revisiting Puzzle 54 (Human Fyn 2)

This is a throwback puzzle to the infancy of Foldit. This protein helps control cell growth.

701: Revisiting CASP ROLL Target R0005

Resetting this CASP ROLL puzzle will cycle through 10 different server predictions. They are also available in the Alignment Tool so you can use partial threading. The secondary structure prediction are posted in the old puzzle comments.

703: De-novo Freestyle 23: Hand-folding Round

We are giving you another currently unsolved protein as an extended chain, but this round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. There are no secondary structure predictions for this puzzle!

702: Second Sepsis Puzzle Round 2

This is Round 2 for Puzzle 697. You will be able to load in your manual saves from 697 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools, or start from scratch! NOTE: If you did not manually save a solution in puzzle 697, you can go back to 697, manually save it, and the solution should appear in your manual saves for this puzzle. PLEASE NOTICE that Valine 32 can be mutated!

700: Revisiting Puzzle 52 (Bacteria Energy)

This is a throwback puzzle to a puzzle that was up the very first week of Foldit. This protein has 103 side chains. It is an energy-coupling protein from bacteria.

699: De-novo Freestyle 22 Round 2

This is Round 2 for Puzzle 693. You will be able to load in your manual saves from 693 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools! NOTE: If you did not manually save a solution in puzzle 693, you can go back to 693, manually save it, and the solution should appear in your manual saves for this puzzle.

697: Second Hand-Folding Sepsis Puzzle

Sugar molecules such as the one here are coated on the surface of many human pathogens. We are attempting to increase the protein-sugar binding interactions by allowing you to redesign & insert up to 6 residues to form additional hydrogen bonds with the sugar. To encourage this, only GUI scripts are allowed, and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You will be able to load in your solutions from the first puzzle and refine them with scripting and sharing. Please read the new puzzle comments for more details. AND PLEASE NOTICE that Valine 32 can be mutated!

698: Human cancer protein interaction network target

The solution structure of this dead ringer-like protein has already been solved using NMR, but the crystal structure has yet to be released. We are giving you all 20 models from the NMR ensemble. Every time you reset the puzzle it will cycle through these 20 structures and they are available in the Alignment Tool so you can use partial threading between them. We look forward to seeing how close to the crystal structure you are able to get!

698 (<15): Human cancer protein interaction network target

The solution structure of this dead ringer-like protein has already been solved using NMR, but the crystal structure has yet to be released. We are giving you all 20 models from the NMR ensemble. Every time you reset the puzzle it will cycle through these 20 structures and they are available in the Alignment Tool so you can use partial threading between them. We look forward to seeing how close to the crystal structure you are able to get! For players with fewer than 15 global points.